Evaluation of critical parameters for preparation of stable clove oil nanoemulsion
In this work, the effects of various factors, including the ultrasonic duty cycle and intensity of ultrasonic irradiation, ultrasonication and clove oil content in production of clove oil nanoemulsion were investigated. In preparation of nanoemulsion Tween® 80/Span® 80 as nonionic surfactants via ul...
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doaj-3337ce6ecd2a4a188b1f18394dec01282020-11-24T21:22:38ZengElsevierArabian Journal of Chemistry1878-53522019-12-0112832253230Evaluation of critical parameters for preparation of stable clove oil nanoemulsionMohammad Hassan Shahavi0Morteza Hosseini1Mohsen Jahanshahi2Rikke Louise Meyer3Ghasem Najafpour Darzi4Nanotechnology Research Institute, Faculty of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Iran; Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, DenmarkNanotechnology Research Institute, Faculty of Chemical Engineering, Babol Noshirvani University of Technology, Babol, IranNanotechnology Research Institute, Faculty of Chemical Engineering, Babol Noshirvani University of Technology, Babol, IranInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, DenmarkNanotechnology Research Institute, Faculty of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Iran; Corresponding author. Tel.: +98 11 3233 4204; fax: +98 11 3231 0975.In this work, the effects of various factors, including the ultrasonic duty cycle and intensity of ultrasonic irradiation, ultrasonication and clove oil content in production of clove oil nanoemulsion were investigated. In preparation of nanoemulsion Tween® 80/Span® 80 as nonionic surfactants via ultrasonic emulsification method was used. The average droplets size of clove oil nanoemulsion decreased with an increase in duty cycle; whereas pulsed ultrasound with proper intervals was more efficient than continuous ultrasonication. In order to replace the use of organic solvent and increase the dispersity of active ingredient, suitable emulsifiers were used. The nanopesticides made by ultrasound at optimum formula conditions were defined at ultrasonication time of 300 s, surfactants concentration of 5 wt%, hydrophilic–lipophilic balance number of 9, duty cycle 0.75% and ultrasonic intensity 208 W/cm2. The stability of droplets size of nanoemulsions for duration of 6 months was evaluated. Stable nanoemulsion clove oil with 10 wt% of clove oil content was formulated at optimum conditions with average droplets size around 43 nm at the beginning and after 6 months nanoemulsions re-sized and it was around 100 nm. A stable nanoemulsion of clove oil in water with suitable droplets size as a nanopesticide was prepared. Keywords: Clove oil, Nanoemulsion, Nonionic surfactants, Oil in water emulsion, Ultrasonicationhttp://www.sciencedirect.com/science/article/pii/S1878535215002646 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Hassan Shahavi Morteza Hosseini Mohsen Jahanshahi Rikke Louise Meyer Ghasem Najafpour Darzi |
spellingShingle |
Mohammad Hassan Shahavi Morteza Hosseini Mohsen Jahanshahi Rikke Louise Meyer Ghasem Najafpour Darzi Evaluation of critical parameters for preparation of stable clove oil nanoemulsion Arabian Journal of Chemistry |
author_facet |
Mohammad Hassan Shahavi Morteza Hosseini Mohsen Jahanshahi Rikke Louise Meyer Ghasem Najafpour Darzi |
author_sort |
Mohammad Hassan Shahavi |
title |
Evaluation of critical parameters for preparation of stable clove oil nanoemulsion |
title_short |
Evaluation of critical parameters for preparation of stable clove oil nanoemulsion |
title_full |
Evaluation of critical parameters for preparation of stable clove oil nanoemulsion |
title_fullStr |
Evaluation of critical parameters for preparation of stable clove oil nanoemulsion |
title_full_unstemmed |
Evaluation of critical parameters for preparation of stable clove oil nanoemulsion |
title_sort |
evaluation of critical parameters for preparation of stable clove oil nanoemulsion |
publisher |
Elsevier |
series |
Arabian Journal of Chemistry |
issn |
1878-5352 |
publishDate |
2019-12-01 |
description |
In this work, the effects of various factors, including the ultrasonic duty cycle and intensity of ultrasonic irradiation, ultrasonication and clove oil content in production of clove oil nanoemulsion were investigated. In preparation of nanoemulsion Tween® 80/Span® 80 as nonionic surfactants via ultrasonic emulsification method was used. The average droplets size of clove oil nanoemulsion decreased with an increase in duty cycle; whereas pulsed ultrasound with proper intervals was more efficient than continuous ultrasonication. In order to replace the use of organic solvent and increase the dispersity of active ingredient, suitable emulsifiers were used. The nanopesticides made by ultrasound at optimum formula conditions were defined at ultrasonication time of 300 s, surfactants concentration of 5 wt%, hydrophilic–lipophilic balance number of 9, duty cycle 0.75% and ultrasonic intensity 208 W/cm2. The stability of droplets size of nanoemulsions for duration of 6 months was evaluated. Stable nanoemulsion clove oil with 10 wt% of clove oil content was formulated at optimum conditions with average droplets size around 43 nm at the beginning and after 6 months nanoemulsions re-sized and it was around 100 nm. A stable nanoemulsion of clove oil in water with suitable droplets size as a nanopesticide was prepared. Keywords: Clove oil, Nanoemulsion, Nonionic surfactants, Oil in water emulsion, Ultrasonication |
url |
http://www.sciencedirect.com/science/article/pii/S1878535215002646 |
work_keys_str_mv |
AT mohammadhassanshahavi evaluationofcriticalparametersforpreparationofstablecloveoilnanoemulsion AT mortezahosseini evaluationofcriticalparametersforpreparationofstablecloveoilnanoemulsion AT mohsenjahanshahi evaluationofcriticalparametersforpreparationofstablecloveoilnanoemulsion AT rikkelouisemeyer evaluationofcriticalparametersforpreparationofstablecloveoilnanoemulsion AT ghasemnajafpourdarzi evaluationofcriticalparametersforpreparationofstablecloveoilnanoemulsion |
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