In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid Preparations
Background: Although investigations of the drug aerosols generated from inhaled corticosteroid (ICS) preparations and combined drug preparations provide basic information about inhalation therapy, many clinicians have one-sided data about the precision of drug aerosols from the manufacturer. The pre...
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doaj-333a10ec9ad84cf5be8a4d2ab7f23c102020-11-24T22:09:16ZengElsevierAllergology International1323-89302012-01-0161114915410.2332/allergolint.11-OA-0332In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid PreparationsGen Tamura0Hirokazu Sakae1Satoshi Fujino2Airway Institute in Sendai Co., Ltd., MiyagiTokyo Dylec Corporation, Tokyo, Japan.Tokyo Dylec Corporation, Tokyo, Japan.Background: Although investigations of the drug aerosols generated from inhaled corticosteroid (ICS) preparations and combined drug preparations provide basic information about inhalation therapy, many clinicians have one-sided data about the precision of drug aerosols from the manufacturer. The present study was conducted to analyze and compare the performances of dry powder inhaler (DPI) devices of ICS and combined drug preparations. Methods: The particle size of individual aerosols was measured according to the time-of-flight principle in terms of their aerodynamic diameter by using the aerodynamic particle sizer spectrometer Model 3321. Percent aerosolization was measured using only stage #0 and backup filters of the Andersen non-viable sampler model AN-200. Results: The particle size distribution of aerosols generated from a Turbuhaler™ and Twisthaler™ showed a mono-modal distribution of less than 5 ^m. In contrast, Diskus™ showed a polydisperse distribution, ranging from 0.5 to 20 ^m. The percentages of DPI preparations converted into aerosols with a particle size less than 11 ^m at a suction flow rate of 28.3 L/min were 5.7-6.2% for Diskus, 37.5-47.0% for Turbuhaler, and 19.8% for Twisthaler. At a suction flow rate of 60 L/min, the conversion percentages for DPI preparations into aerosols with a particle size less than 7.6 ^m were 5.9-7.5%, 78.2-86.7%, and 43.5%, respectively. Conclusions: Because in vitro differences in the aerosolization among different DPI devices containing ICS and combined drug preparations were observed, prescribers of these preparations should consider whether the patients will benefit more from the treatment of the central airways versus the peripheral airways.http://www.sciencedirect.com/science/article/pii/S1323893015302057aerosolizationdevicesdry powder inhaler (DPI)inhaled corticosteroid (ICS)particle size |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gen Tamura Hirokazu Sakae Satoshi Fujino |
spellingShingle |
Gen Tamura Hirokazu Sakae Satoshi Fujino In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid Preparations Allergology International aerosolization devices dry powder inhaler (DPI) inhaled corticosteroid (ICS) particle size |
author_facet |
Gen Tamura Hirokazu Sakae Satoshi Fujino |
author_sort |
Gen Tamura |
title |
In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid Preparations |
title_short |
In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid Preparations |
title_full |
In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid Preparations |
title_fullStr |
In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid Preparations |
title_full_unstemmed |
In vitro Evaluation of Dry Powder Inhaler Devices of Corticosteroid Preparations |
title_sort |
in vitro evaluation of dry powder inhaler devices of corticosteroid preparations |
publisher |
Elsevier |
series |
Allergology International |
issn |
1323-8930 |
publishDate |
2012-01-01 |
description |
Background: Although investigations of the drug aerosols generated from inhaled corticosteroid (ICS) preparations and combined drug preparations provide basic information about inhalation therapy, many clinicians have one-sided data about the precision of drug aerosols from the manufacturer. The present study was conducted to analyze and compare the performances of dry powder inhaler (DPI) devices of ICS and combined drug preparations.
Methods: The particle size of individual aerosols was measured according to the time-of-flight principle in terms of their aerodynamic diameter by using the aerodynamic particle sizer spectrometer Model 3321. Percent aerosolization was measured using only stage #0 and backup filters of the Andersen non-viable sampler model AN-200.
Results: The particle size distribution of aerosols generated from a Turbuhaler™ and Twisthaler™ showed a mono-modal distribution of less than 5 ^m. In contrast, Diskus™ showed a polydisperse distribution, ranging from 0.5 to 20 ^m. The percentages of DPI preparations converted into aerosols with a particle size less than 11 ^m at a suction flow rate of 28.3 L/min were 5.7-6.2% for Diskus, 37.5-47.0% for Turbuhaler, and 19.8% for Twisthaler. At a suction flow rate of 60 L/min, the conversion percentages for DPI preparations into aerosols with a particle size less than 7.6 ^m were 5.9-7.5%, 78.2-86.7%, and 43.5%, respectively.
Conclusions: Because in vitro differences in the aerosolization among different DPI devices containing ICS and combined drug preparations were observed, prescribers of these preparations should consider whether the patients will benefit more from the treatment of the central airways versus the peripheral airways. |
topic |
aerosolization devices dry powder inhaler (DPI) inhaled corticosteroid (ICS) particle size |
url |
http://www.sciencedirect.com/science/article/pii/S1323893015302057 |
work_keys_str_mv |
AT gentamura invitroevaluationofdrypowderinhalerdevicesofcorticosteroidpreparations AT hirokazusakae invitroevaluationofdrypowderinhalerdevicesofcorticosteroidpreparations AT satoshifujino invitroevaluationofdrypowderinhalerdevicesofcorticosteroidpreparations |
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