Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study
Probiotics and vitamins can impact immune responses and modulate gut microbiome. We evaluated the effects of consuming a yogurt fortified with vitamins and probiotic Lacticaseibacillus casei and rhamnosus on upper respiratory tract infections frequency and gut microbiome during a 3-month interventio...
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doaj-333ac724c9404aff8f33f768725c3d342021-06-19T04:53:33ZengElsevierJournal of Functional Foods1756-46462021-08-0183104572Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized studyVera Odintsova0Natalia Klimenko1Alexander Tyakht2Olesya Volokh3Vladimir Popov4Dmitry Alexeev5Yulia Berezhnaya6Atlas Biomed Group - Knomics LLC, Tintagel House, 92 Albert Embankment, Lambeth, SE1 7TY London, United KingdomAtlas Biomed Group - Knomics LLC, Tintagel House, 92 Albert Embankment, Lambeth, SE1 7TY London, United Kingdom; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilova str., 119334 Moscow, RussiaAtlas Biomed Group - Knomics LLC, Tintagel House, 92 Albert Embankment, Lambeth, SE1 7TY London, United Kingdom; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilova str., 119334 Moscow, Russia; Corresponding author at: 121069 Malaya Nikitskaya ul. 31a, Moscow, Russia.Lomonosov Moscow State University, Faculty of Biology, 1-12 Leninskie Gory, 119991 Moscow, RussiaN.A. Semashko Clinical Hospital “RZD-Medicine”, Stavropolskaya str. 23 k 1, 109386 Moscow, RussiaAtlas Biomed Group - Knomics LLC, Tintagel House, 92 Albert Embankment, Lambeth, SE1 7TY London, United KingdomPepsiCo R&D, Leningradsky Prospekt 72 k 4, 125319 Moscow, RussiaProbiotics and vitamins can impact immune responses and modulate gut microbiome. We evaluated the effects of consuming a yogurt fortified with vitamins and probiotic Lacticaseibacillus casei and rhamnosus on upper respiratory tract infections frequency and gut microbiome during a 3-month intervention. The study included 2 case groups (consuming different flavours) and a placebo group of healthy adults (n = 158–160 in each group). The effects on URTI-related parameters in both case groups were gender-specific. The female subjects had lower URTI incidence and frequency, while for the males no significant differences were found. The URTI duration was shorter in one of the probiotic groups for females and in both such groups - for males. The observed changes in microbiome composition, blood and stool parameters were not different from those observed in the placebo group. Consumption of fortified fermented dairy foods is promising for improving immunity status within the general population.http://www.sciencedirect.com/science/article/pii/S1756464621002218ProbioticsVitaminsLacticaseibacillusRespiratory tract infectionsImmunity16S rRNA sequencing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vera Odintsova Natalia Klimenko Alexander Tyakht Olesya Volokh Vladimir Popov Dmitry Alexeev Yulia Berezhnaya |
spellingShingle |
Vera Odintsova Natalia Klimenko Alexander Tyakht Olesya Volokh Vladimir Popov Dmitry Alexeev Yulia Berezhnaya Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study Journal of Functional Foods Probiotics Vitamins Lacticaseibacillus Respiratory tract infections Immunity 16S rRNA sequencing |
author_facet |
Vera Odintsova Natalia Klimenko Alexander Tyakht Olesya Volokh Vladimir Popov Dmitry Alexeev Yulia Berezhnaya |
author_sort |
Vera Odintsova |
title |
Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study |
title_short |
Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study |
title_full |
Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study |
title_fullStr |
Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study |
title_full_unstemmed |
Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study |
title_sort |
yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: a multicenter double-blind placebo controlled randomized study |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2021-08-01 |
description |
Probiotics and vitamins can impact immune responses and modulate gut microbiome. We evaluated the effects of consuming a yogurt fortified with vitamins and probiotic Lacticaseibacillus casei and rhamnosus on upper respiratory tract infections frequency and gut microbiome during a 3-month intervention. The study included 2 case groups (consuming different flavours) and a placebo group of healthy adults (n = 158–160 in each group). The effects on URTI-related parameters in both case groups were gender-specific. The female subjects had lower URTI incidence and frequency, while for the males no significant differences were found. The URTI duration was shorter in one of the probiotic groups for females and in both such groups - for males. The observed changes in microbiome composition, blood and stool parameters were not different from those observed in the placebo group. Consumption of fortified fermented dairy foods is promising for improving immunity status within the general population. |
topic |
Probiotics Vitamins Lacticaseibacillus Respiratory tract infections Immunity 16S rRNA sequencing |
url |
http://www.sciencedirect.com/science/article/pii/S1756464621002218 |
work_keys_str_mv |
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