Multimorbidity prediction using link prediction
Abstract Multimorbidity, frequently associated with aging, can be operationally defined as the presence of two or more chronic conditions. Predicting the likelihood of a patient with multimorbidity to develop a further particular disease in the future is one of the key challenges in multimorbidity r...
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doaj-3345541b904c4ba69daa4518344daf8f2021-08-15T11:24:16ZengNature Publishing GroupScientific Reports2045-23222021-08-0111111110.1038/s41598-021-95802-0Multimorbidity prediction using link predictionFurqan Aziz0Victor Roth Cardoso1Laura Bravo-Merodio2Dominic Russ3Samantha C. Pendleton4John A. Williams5Animesh Acharjee6Georgios V. Gkoutos7Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, University of BirminghamAbstract Multimorbidity, frequently associated with aging, can be operationally defined as the presence of two or more chronic conditions. Predicting the likelihood of a patient with multimorbidity to develop a further particular disease in the future is one of the key challenges in multimorbidity research. In this paper we are using a network-based approach to analyze multimorbidity data and develop methods for predicting diseases that a patient is likely to develop. The multimorbidity data is represented using a temporal bipartite network whose nodes represent patients and diseases and a link between these nodes indicates that the patient has been diagnosed with the disease. Disease prediction then is reduced to a problem of predicting those missing links in the network that are likely to appear in the future. We develop a novel link prediction method for static bipartite network and validate the performance of the method on benchmark datasets. By using a probabilistic framework, we then report on the development of a method for predicting future links in the network, where links are labelled with a time-stamp. We apply the proposed method to three different multimorbidity datasets and report its performance measured by different performance metrics including AUC, Precision, Recall, and F-Score.https://doi.org/10.1038/s41598-021-95802-0 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Furqan Aziz Victor Roth Cardoso Laura Bravo-Merodio Dominic Russ Samantha C. Pendleton John A. Williams Animesh Acharjee Georgios V. Gkoutos |
spellingShingle |
Furqan Aziz Victor Roth Cardoso Laura Bravo-Merodio Dominic Russ Samantha C. Pendleton John A. Williams Animesh Acharjee Georgios V. Gkoutos Multimorbidity prediction using link prediction Scientific Reports |
author_facet |
Furqan Aziz Victor Roth Cardoso Laura Bravo-Merodio Dominic Russ Samantha C. Pendleton John A. Williams Animesh Acharjee Georgios V. Gkoutos |
author_sort |
Furqan Aziz |
title |
Multimorbidity prediction using link prediction |
title_short |
Multimorbidity prediction using link prediction |
title_full |
Multimorbidity prediction using link prediction |
title_fullStr |
Multimorbidity prediction using link prediction |
title_full_unstemmed |
Multimorbidity prediction using link prediction |
title_sort |
multimorbidity prediction using link prediction |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-08-01 |
description |
Abstract Multimorbidity, frequently associated with aging, can be operationally defined as the presence of two or more chronic conditions. Predicting the likelihood of a patient with multimorbidity to develop a further particular disease in the future is one of the key challenges in multimorbidity research. In this paper we are using a network-based approach to analyze multimorbidity data and develop methods for predicting diseases that a patient is likely to develop. The multimorbidity data is represented using a temporal bipartite network whose nodes represent patients and diseases and a link between these nodes indicates that the patient has been diagnosed with the disease. Disease prediction then is reduced to a problem of predicting those missing links in the network that are likely to appear in the future. We develop a novel link prediction method for static bipartite network and validate the performance of the method on benchmark datasets. By using a probabilistic framework, we then report on the development of a method for predicting future links in the network, where links are labelled with a time-stamp. We apply the proposed method to three different multimorbidity datasets and report its performance measured by different performance metrics including AUC, Precision, Recall, and F-Score. |
url |
https://doi.org/10.1038/s41598-021-95802-0 |
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