An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established m...

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Main Authors: Alexander J. Hron, Atsushi Asakura
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2017/2480375
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spelling doaj-3353a9f4a428421cb65d73fcc01cd2832020-11-25T00:12:18ZengHindawi LimitedStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/24803752480375An Examination of the Role of Transcriptional and Posttranscriptional Regulation in RhabdomyosarcomaAlexander J. Hron0Atsushi Asakura1Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USAStem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USARhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.http://dx.doi.org/10.1155/2017/2480375
collection DOAJ
language English
format Article
sources DOAJ
author Alexander J. Hron
Atsushi Asakura
spellingShingle Alexander J. Hron
Atsushi Asakura
An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
Stem Cells International
author_facet Alexander J. Hron
Atsushi Asakura
author_sort Alexander J. Hron
title An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_short An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_full An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_fullStr An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_full_unstemmed An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_sort examination of the role of transcriptional and posttranscriptional regulation in rhabdomyosarcoma
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2017-01-01
description Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.
url http://dx.doi.org/10.1155/2017/2480375
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