SUV variability in EARL-accredited conventional and digital PET
Abstract Background A high SUV-reproducibility is crucial when different PET scanners are in use. We evaluated the SUV variability in whole-body FDG-PET scans of patients with suspected or proven cancer using an EARL-accredited conventional and digital PET scanner. In a head-to-head comparison we st...
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doaj-3356ba6cb46e430f98d1c4231c8193e92020-12-13T12:18:35ZengSpringerOpenEJNMMI Research2191-219X2019-12-01911810.1186/s13550-019-0569-7SUV variability in EARL-accredited conventional and digital PETDaniëlle Koopman0Pieter L. Jager1Cornelis H. Slump2Siert Knollema3Jorn A. van Dalen4Department of Nuclear Medicine, IsalaDepartment of Nuclear Medicine, IsalaTechnical Medicine Center, University of TwenteDepartment of Nuclear Medicine, IsalaDepartment of Medical Physics, IsalaAbstract Background A high SUV-reproducibility is crucial when different PET scanners are in use. We evaluated the SUV variability in whole-body FDG-PET scans of patients with suspected or proven cancer using an EARL-accredited conventional and digital PET scanner. In a head-to-head comparison we studied images of 50 patients acquired on a conventional scanner (cPET, Ingenuity TF PET/CT, Philips) and compared them with images acquired on a digital scanner (dPET, Vereos PET/CT, Philips). The PET scanning order was randomised and EARL-compatible reconstructions were applied. We measured SUVmean, SUVpeak, SUVmax and lesion diameter in up to 5 FDG-positive lesions per patient. The relative difference ΔSUV between cPET and dPET was calculated for each SUV-parameter. Furthermore, we calculated repeatability coefficients, reflecting the 95% confidence interval of ΔSUV. Results We included 128 lesions with an average size of 19 ± 14 mm. Average ΔSUVs were 6-8% with dPET values being higher for all three SUV-parameters (p < 0.001). ΔSUVmax was significantly higher than ΔSUVmean (8% vs. 6%, p = 0.002) and than ΔSUVpeak (8% vs. 7%, p = 0.03). Repeatability coefficients across individual lesions were 27% (ΔSUVmean and ΔSUVpeak) and 33% (ΔSUVmax) (p < 0.001). Conclusions With EARL-accredited conventional and digital PET, we found a limited SUV variability with average differences up to 8%. Furthermore, only a limited number of lesions showed a SUV difference of more than 30%. These findings indicate that EARL standardisation works. Trial registration This prospective study was registered on the 31th of October 2017 at ClinicalTrials.cov. URL: https://clinicaltrials.gov/ct2/show/NCT03457506?id=03457506&rank=1.https://doi.org/10.1186/s13550-019-0569-7FDG-PETEARL-accreditationConventional PETDigital PETCancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniëlle Koopman Pieter L. Jager Cornelis H. Slump Siert Knollema Jorn A. van Dalen |
spellingShingle |
Daniëlle Koopman Pieter L. Jager Cornelis H. Slump Siert Knollema Jorn A. van Dalen SUV variability in EARL-accredited conventional and digital PET EJNMMI Research FDG-PET EARL-accreditation Conventional PET Digital PET Cancer |
author_facet |
Daniëlle Koopman Pieter L. Jager Cornelis H. Slump Siert Knollema Jorn A. van Dalen |
author_sort |
Daniëlle Koopman |
title |
SUV variability in EARL-accredited conventional and digital PET |
title_short |
SUV variability in EARL-accredited conventional and digital PET |
title_full |
SUV variability in EARL-accredited conventional and digital PET |
title_fullStr |
SUV variability in EARL-accredited conventional and digital PET |
title_full_unstemmed |
SUV variability in EARL-accredited conventional and digital PET |
title_sort |
suv variability in earl-accredited conventional and digital pet |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2019-12-01 |
description |
Abstract Background A high SUV-reproducibility is crucial when different PET scanners are in use. We evaluated the SUV variability in whole-body FDG-PET scans of patients with suspected or proven cancer using an EARL-accredited conventional and digital PET scanner. In a head-to-head comparison we studied images of 50 patients acquired on a conventional scanner (cPET, Ingenuity TF PET/CT, Philips) and compared them with images acquired on a digital scanner (dPET, Vereos PET/CT, Philips). The PET scanning order was randomised and EARL-compatible reconstructions were applied. We measured SUVmean, SUVpeak, SUVmax and lesion diameter in up to 5 FDG-positive lesions per patient. The relative difference ΔSUV between cPET and dPET was calculated for each SUV-parameter. Furthermore, we calculated repeatability coefficients, reflecting the 95% confidence interval of ΔSUV. Results We included 128 lesions with an average size of 19 ± 14 mm. Average ΔSUVs were 6-8% with dPET values being higher for all three SUV-parameters (p < 0.001). ΔSUVmax was significantly higher than ΔSUVmean (8% vs. 6%, p = 0.002) and than ΔSUVpeak (8% vs. 7%, p = 0.03). Repeatability coefficients across individual lesions were 27% (ΔSUVmean and ΔSUVpeak) and 33% (ΔSUVmax) (p < 0.001). Conclusions With EARL-accredited conventional and digital PET, we found a limited SUV variability with average differences up to 8%. Furthermore, only a limited number of lesions showed a SUV difference of more than 30%. These findings indicate that EARL standardisation works. Trial registration This prospective study was registered on the 31th of October 2017 at ClinicalTrials.cov. URL: https://clinicaltrials.gov/ct2/show/NCT03457506?id=03457506&rank=1. |
topic |
FDG-PET EARL-accreditation Conventional PET Digital PET Cancer |
url |
https://doi.org/10.1186/s13550-019-0569-7 |
work_keys_str_mv |
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