Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase

Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase

Hepatitis C virus (HCV) is an important etiological agent of severe liver diseases, including cirrhosis and hepatocellular carcinoma. The HCV genome encodes nonstructural protein 3 (NS3) helicase, which is a potential anti-HCV drug target because its enzymatic activity is essential for viral replica...

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Bibliographic Details
Main Authors: Atsushi Furuta, Masayoshi Tsubuki, Miduki Endoh, Tatsuki Miyamoto, Junichi Tanaka, Kazi Abdus Salam, Nobuyoshi Akimitsu, Hidenori Tani, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Yuji Sekiguchi, Satoshi Tsuneda, Naohiro Noda
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis C virus
NS3 helicase
fluorescence resonance energy transfer
inhibitor
hydroxyanthraquinone
hypericin
sennidin A
Online Access:http://www.mdpi.com/1422-0067/16/8/18439

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