miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that dysfunction of miR-135a-5p/Rock2/Add1 results in mem...
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22196-y |
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doaj-3366a3bed29948729d65876a46ebc7a72021-03-28T11:12:38ZengNature Publishing GroupNature Communications2041-17232021-03-0112111610.1038/s41467-021-22196-ymiR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s diseaseKai Zheng0Fan Hu1Yang Zhou2Juan Zhang3Jie Zheng4Chuan Lai5Wan Xiong6Ke Cui7Ya-Zhuo Hu8Zhi-Tao Han9Hong-Hong Zhang10Jian-Guo Chen11Heng-Ye Man12Dan Liu13Youming Lu14Ling-Qiang Zhu15Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyBeijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Institute of Geriatrics, Chinese PLA General Hospital and Chinese PLA Medical AcademyBeijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Institute of Geriatrics, Chinese PLA General Hospital and Chinese PLA Medical AcademyBeijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Institute of Geriatrics, Chinese PLA General Hospital and Chinese PLA Medical AcademyThe Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and TechnologyDepartment of Biology, Boston UniversityThe Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and TechnologyThe Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and TechnologyDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologySeveral micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in AD.https://doi.org/10.1038/s41467-021-22196-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kai Zheng Fan Hu Yang Zhou Juan Zhang Jie Zheng Chuan Lai Wan Xiong Ke Cui Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Guo Chen Heng-Ye Man Dan Liu Youming Lu Ling-Qiang Zhu |
| spellingShingle |
Kai Zheng Fan Hu Yang Zhou Juan Zhang Jie Zheng Chuan Lai Wan Xiong Ke Cui Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Guo Chen Heng-Ye Man Dan Liu Youming Lu Ling-Qiang Zhu miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease Nature Communications |
| author_facet |
Kai Zheng Fan Hu Yang Zhou Juan Zhang Jie Zheng Chuan Lai Wan Xiong Ke Cui Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Guo Chen Heng-Ye Man Dan Liu Youming Lu Ling-Qiang Zhu |
| author_sort |
Kai Zheng |
| title |
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease |
| title_short |
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease |
| title_full |
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease |
| title_fullStr |
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease |
| title_full_unstemmed |
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease |
| title_sort |
mir-135a-5p mediates memory and synaptic impairments via the rock2/adducin1 signaling pathway in a mouse model of alzheimer’s disease |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in AD. |
| url |
https://doi.org/10.1038/s41467-021-22196-y |
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