Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
LncRNAs regulate gene expression via their RNA product and through transcriptional interference. Here, Stojic et al.uncouple these functions by using multiple siRNAs against GNG12-AS1 to show that this lncRNA has a product related role in MET signaling while its transcription modulates DIRAS3 expres...
Main Authors: | Lovorka Stojic, Malwina Niemczyk, Arturo Orjalo, Yoko Ito, Anna Elisabeth Maria Ruijter, Santiago Uribe-Lewis, Nimesh Joseph, Stephen Weston, Suraj Menon, Duncan T. Odom, John Rinn, Fanni Gergely, Adele Murrell |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms10406 |
Similar Items
-
Epigenetic and transcriptional relationship between a novel long non-coding RNA GNG12-AS1 and imprinted DIRAS3
by: Niemczyk, Malwina
Published: (2014) -
Uncoupling transcription from covalent histone modification.
by: Hesheng Zhang, et al.
Published: (2014-04-01) -
3D Maps Representation Using GNG
by: Vicente Morell, et al.
Published: (2014-01-01) -
Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription
by: Jatinder Kaur Gill, et al.
Published: (2020-05-01) -
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division
by: Lovorka Stojic, et al.
Published: (2020-04-01)