Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interes...

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Main Authors:	Marco Scarel, Silvia Marchesan
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Molecules
Subjects:	cyclopeptides diketopiperazines gels hydrogels peptides amino acids
Online Access:	https://www.mdpi.com/1420-3049/26/11/3376

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spelling	doaj-3375ea1e8c9d42c0991df0967f4d16c42021-06-30T23:10:57ZengMDPI AGMolecules1420-30492021-06-01263376337610.3390/molecules26113376Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic DipeptidesMarco Scarel0Silvia Marchesan1Chemical and Pharmaceutical Sciences Department, University of Trieste, Via Giorgieri 1, 34127 Trieste, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, Via Giorgieri 1, 34127 Trieste, ItalyCyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.https://www.mdpi.com/1420-3049/26/11/3376cyclopeptidesdiketopiperazinesgelshydrogelspeptidesamino acids
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marco Scarel Silvia Marchesan
spellingShingle	Marco Scarel Silvia Marchesan Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides Molecules cyclopeptides diketopiperazines gels hydrogels peptides amino acids
author_facet	Marco Scarel Silvia Marchesan
author_sort	Marco Scarel
title	Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_short	Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_full	Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_fullStr	Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_full_unstemmed	Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_sort	diketopiperazine gels: new horizons from the self-assembly of cyclic dipeptides
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-06-01
description	Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.
topic	cyclopeptides diketopiperazines gels hydrogels peptides amino acids
url	https://www.mdpi.com/1420-3049/26/11/3376
work_keys_str_mv	AT marcoscarel diketopiperazinegelsnewhorizonsfromtheselfassemblyofcyclicdipeptides AT silviamarchesan diketopiperazinegelsnewhorizonsfromtheselfassemblyofcyclicdipeptides
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Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

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