Targeted-Gene Sequencing to Catch Triple Negative Breast Cancer Heterogeneity before and after Neoadjuvant Chemotherapy

Targeted-Gene Sequencing to Catch Triple Negative Breast Cancer Heterogeneity before and after Neoadjuvant Chemotherapy

Triple negative breast cancer (TNBC) patients not attaining pathological Complete Response (pCR) after neo-adjuvant chemotherapy (NAC) have poor prognosis. We characterized 19 patients for somatic mutations in primary tumor biopsy and residual disease (RD) at surgery by 409 cancer-related gene seque...

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Bibliographic Details
Main Authors: Serena Di Cosimo, Valentina Appierto, Marco Silvestri, Giancarlo Pruneri, Andrea Vingiani, Federica Perrone, Adele Busico, Secondo Folli, Gianfranco Scaperrotta, Filippo Guglielmo de Braud, Giulia Valeria Bianchi, Stefano Cavalieri, Maria Grazia Daidone, Matteo Dugo
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
targeted-gene sequencing
heterogeneity
biopsies
neo-adjuvant chemotherapy
triple negative breast cancer
somatic mutations
cancer therapy
Online Access:https://www.mdpi.com/2072-6694/11/11/1753

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