Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease
Impulse control disorders (ICDs) in Parkinson's disease (PD) have a high cumulative incidence and negatively impact quality of life. ICDs are influenced by a complex interaction of multiple factors. Although it is now well-recognized that dopaminergic treatments and especially dopamine agonists...
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doaj-3387fc619c93465f9ac61bc15bc5b7c42020-11-24T21:20:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-02-011010.3389/fneur.2019.00086429227Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's DiseaseRobert S. Eisinger0Adolfo Ramirez-Zamora1Samuel Carbunaru2Brandon Ptak3Zhongxing Peng-Chen4Michael S. Okun5Michael S. Okun6Aysegul Gunduz7Aysegul Gunduz8Department of Neuroscience, University of Florida, Gainesville, FL, United StatesHospital Padre Hurtado, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, ChileDepartment of Neuroscience, University of Florida, Gainesville, FL, United StatesDepartment of Neuroscience, University of Florida, Gainesville, FL, United StatesHospital Padre Hurtado, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, ChileDepartment of Neuroscience, University of Florida, Gainesville, FL, United StatesDepartment of Neurology, Fixel Center for Neurological Diseases, University of Florida, Gainesville, FL, United StatesDepartment of Neuroscience, University of Florida, Gainesville, FL, United StatesDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United StatesImpulse control disorders (ICDs) in Parkinson's disease (PD) have a high cumulative incidence and negatively impact quality of life. ICDs are influenced by a complex interaction of multiple factors. Although it is now well-recognized that dopaminergic treatments and especially dopamine agonists underpin many ICDs, medications alone are not the sole cause. Susceptibility to ICD is increased in the setting of PD. While causality can be challenging to ascertain, a wide range of modifiable and non-modifiable risk factors have been linked to ICDs. Common characteristics of PD patients with ICDs have been consistently identified across many studies; for example, males with an early age of PD onset and dopamine agonist use have a higher risk of ICD. However, not all cases of ICDs in PD can be directly attributable to dopamine, and studies have concluded that additional factors such as genetics, smoking, and/or depression may be more predictive. Beyond dopamine, other ICD associations have been described but remain difficult to explain, including deep brain stimulation surgery, especially in the setting of a reduction in dopaminergic medication use. In this review, we will summarize the demographic, genetic, behavioral, and clinical contributions potentially influencing ICD onset in PD. These associations may inspire future preventative or therapeutic strategies.https://www.frontiersin.org/article/10.3389/fneur.2019.00086/fullimpulse control disorderParkinson's diseaseimpulsivitydopaminergic medicationsdeep brain stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robert S. Eisinger Adolfo Ramirez-Zamora Samuel Carbunaru Brandon Ptak Zhongxing Peng-Chen Michael S. Okun Michael S. Okun Aysegul Gunduz Aysegul Gunduz |
spellingShingle |
Robert S. Eisinger Adolfo Ramirez-Zamora Samuel Carbunaru Brandon Ptak Zhongxing Peng-Chen Michael S. Okun Michael S. Okun Aysegul Gunduz Aysegul Gunduz Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease Frontiers in Neurology impulse control disorder Parkinson's disease impulsivity dopaminergic medications deep brain stimulation |
author_facet |
Robert S. Eisinger Adolfo Ramirez-Zamora Samuel Carbunaru Brandon Ptak Zhongxing Peng-Chen Michael S. Okun Michael S. Okun Aysegul Gunduz Aysegul Gunduz |
author_sort |
Robert S. Eisinger |
title |
Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease |
title_short |
Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease |
title_full |
Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease |
title_fullStr |
Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease |
title_full_unstemmed |
Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease |
title_sort |
medications, deep brain stimulation, and other factors influencing impulse control disorders in parkinson's disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2019-02-01 |
description |
Impulse control disorders (ICDs) in Parkinson's disease (PD) have a high cumulative incidence and negatively impact quality of life. ICDs are influenced by a complex interaction of multiple factors. Although it is now well-recognized that dopaminergic treatments and especially dopamine agonists underpin many ICDs, medications alone are not the sole cause. Susceptibility to ICD is increased in the setting of PD. While causality can be challenging to ascertain, a wide range of modifiable and non-modifiable risk factors have been linked to ICDs. Common characteristics of PD patients with ICDs have been consistently identified across many studies; for example, males with an early age of PD onset and dopamine agonist use have a higher risk of ICD. However, not all cases of ICDs in PD can be directly attributable to dopamine, and studies have concluded that additional factors such as genetics, smoking, and/or depression may be more predictive. Beyond dopamine, other ICD associations have been described but remain difficult to explain, including deep brain stimulation surgery, especially in the setting of a reduction in dopaminergic medication use. In this review, we will summarize the demographic, genetic, behavioral, and clinical contributions potentially influencing ICD onset in PD. These associations may inspire future preventative or therapeutic strategies. |
topic |
impulse control disorder Parkinson's disease impulsivity dopaminergic medications deep brain stimulation |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.00086/full |
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