Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity.

Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity.

Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation has on tumorigenesis is not completely known. To examine its effect on tumorigen...

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Bibliographic Details
Main Authors:	Christopher A Hamm, Hehuang Xie, Fabricio F Costa, Elio F Vanin, Elisabeth A Seftor, Simone T Sredni, Jared Bischof, Deli Wang, Maria F Bonaldo, Mary J C Hendrix, Marcelo B Soares
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-12-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2790612?pdf=render

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