CORRELATION BETWEEN Β-HYDROXYBUTYRATE (Β-OHB) CONCENTRATION AND BICARBONATE LEVEL IN EARLY REGULATION OF BLOOD SUGAR ON DIABETIC KETOACIDOSIS PATIENTS IN RSUD DR. SAIFUL ANWAR MALANG, INDONESIA

• Main Authors: Titis W.S., Catur S.S., Nanik S., Antonius F.
• Format: Article
• Language: English
• Published: Biotika 2019-02-01
• Series: Biotika
• Subjects: Diabetic ketoacidosis; β-hydroxybutyrate; bicarbonate; insulin
• Online Access: https://journal-biotika.com/current-issues/2019-01/article_03.pdf

One of the acute complications of diabetes mellitus is diabetic ketoacidosis (DKA). DKA is characterized by glucose levels ≥14mmol/l (≥250mg/dL), acidosis pH <7.3, bicarbonate (HCO3) <18mEq/L, ketonemia, ketonuria. Currently in RSUD dr. Saiful Anwar, there is a β-hydroxybutyrate (β-OHB) examination by using a POCT ketone meter to facilitate clinical diagnosis and monitoring of DKA patients. The aim of this research is to analyze the correlation between the level of β-OHB and HCO3 on initial insulin regulation in DKA patients. The research method used is observational analytic, cross-sectional in which the data is retrieved in time series. A total of 15 subjects are included in the inclusion criteria. Research shows that there is a correlation between HCO3 and β-OHB levels after initial insulin regulation (p = 0.012 and r = −0.628). There were significant differences in the levels of HCO3, β-OHB before and after insulin regulation with p-value of 0.001 and 0.015, respectively. There is a match between HCO3 and β-OHB after insulin regulation (p = 0.250). It can be concluded that HCO3 and β-OHB in the administration of initial insulin regulation correlate strongly. Thus, β-OHB can be used instead of HCO3.