GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
Objective: To establish the correlation between glycated hemoglobin (HbA1c) and lipid profile in patients with type 2 diabetes mellitus (T2DM). Study Design: Correlation study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi (PEMH), Medical Outpatient department (OPD), f...
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doaj-339ccf1fff1a477a9b7997d95bae70a22021-09-13T04:17:33ZengThe Army PressPakistan Armed Forces Medical Journal0030-96482411-88422020-10-0170515811585GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUSAbdul Moueed Tariq0Abdul Latif Khattak1Hafiz Yasir Rehman2Faisal Mehmood3Raheel Akhtar4Ejaz Ali5Combined Military Hospital, Quetta/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital, Quetta/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital, Quetta/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital, Quetta/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital, Quetta/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital, Quetta/National University of Medical Sciences (NUMS) PakistanObjective: To establish the correlation between glycated hemoglobin (HbA1c) and lipid profile in patients with type 2 diabetes mellitus (T2DM). Study Design: Correlation study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi (PEMH), Medical Outpatient department (OPD), from Nov 2017 to May 2018. Methodology: A total of 160 patients with type 2 diabetes mellitus of both genders, 30-70 years of age presenting in OPD were included in study, while those with T1DM, CKD stage 3 and above, infection or diabetic foot, any endocrine disease and female patients with pregnancy were excluded from the study. The blood samples were taken for blood sugar random (BSR), blood sugar fasting (BSF), haemoglobin A1c (HbA1c), lipid profile and results were collected next day. The Pearson correlation test was used to analyze correlations. Results: Among 160 patients the mean age was 57.28 ± 10.13 years, 81 (50.6%) were males while 79 (49.4%) were females. The 34 (21.20%) patients had good, while 125 (78.80%) had poor glycaemic control using haemoglobin A1c of 7% as a cut off. A positive and statistically significant correlation was observed between haemoglobin A1c and total cholesterol (r=0.233, p<0.01), triglycerides (r=0.172, p<0.05), and a correlation which was positive but statistically not significant was observed between haemoglobin A1c and LDL-C (r=0.105, p=0.260) while a statistically insignificant negative correlation was observed between haemoglobin A1c and HDL-C (r=-0.041, p=0.652). Conclusion: A significant positive correlation was found between haemoglobin A1c and total cholesterol and triglycerides. Haemoglobin A1c can also be used as a biomarker to predict dyslipidemias in patients with type 2 diabetes mellitus.https://pafmj.org/index.php/PAFMJ/article/view/5609dyslipidemiaglycated hemoglobintype 2 dm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdul Moueed Tariq Abdul Latif Khattak Hafiz Yasir Rehman Faisal Mehmood Raheel Akhtar Ejaz Ali |
spellingShingle |
Abdul Moueed Tariq Abdul Latif Khattak Hafiz Yasir Rehman Faisal Mehmood Raheel Akhtar Ejaz Ali GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS Pakistan Armed Forces Medical Journal dyslipidemia glycated hemoglobin type 2 dm |
author_facet |
Abdul Moueed Tariq Abdul Latif Khattak Hafiz Yasir Rehman Faisal Mehmood Raheel Akhtar Ejaz Ali |
author_sort |
Abdul Moueed Tariq |
title |
GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS |
title_short |
GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS |
title_full |
GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS |
title_fullStr |
GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS |
title_full_unstemmed |
GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS |
title_sort |
glycated hemoglobin as a biomarker to predict dyslipidemia in type 2 diabetes mellitus |
publisher |
The Army Press |
series |
Pakistan Armed Forces Medical Journal |
issn |
0030-9648 2411-8842 |
publishDate |
2020-10-01 |
description |
Objective: To establish the correlation between glycated hemoglobin (HbA1c) and lipid profile in patients with type 2 diabetes mellitus (T2DM).
Study Design: Correlation study.
Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi (PEMH), Medical Outpatient department (OPD), from Nov 2017 to May 2018.
Methodology: A total of 160 patients with type 2 diabetes mellitus of both genders, 30-70 years of age presenting in OPD were included in study, while those with T1DM, CKD stage 3 and above, infection or diabetic foot, any endocrine disease and female patients with pregnancy were excluded from the study. The blood samples were taken for blood sugar random (BSR), blood sugar fasting (BSF), haemoglobin A1c (HbA1c), lipid profile and results were collected next day. The Pearson correlation test was used to analyze correlations.
Results: Among 160 patients the mean age was 57.28 ± 10.13 years, 81 (50.6%) were males while 79 (49.4%) were females. The 34 (21.20%) patients had good, while 125 (78.80%) had poor glycaemic control using haemoglobin A1c of 7% as a cut off. A positive and statistically significant correlation was observed between haemoglobin A1c and total cholesterol (r=0.233, p<0.01), triglycerides (r=0.172, p<0.05), and a correlation which was positive but statistically not significant was observed between haemoglobin A1c and LDL-C (r=0.105, p=0.260) while a statistically insignificant negative correlation was observed between haemoglobin A1c and HDL-C (r=-0.041, p=0.652).
Conclusion: A significant positive correlation was found between haemoglobin A1c and total cholesterol and triglycerides. Haemoglobin A1c can also be used as a biomarker to predict dyslipidemias in patients with type 2 diabetes mellitus. |
topic |
dyslipidemia glycated hemoglobin type 2 dm |
url |
https://pafmj.org/index.php/PAFMJ/article/view/5609 |
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