Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload

Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload

Volume overload leads to development of eccentric cardiac hypertrophy and heart failure. In our previous report, we have shown myocyte hypertrophy with no fibrosis and decrease in gap junctional coupling via connexin43 in a rat model of aorto-caval fistula at 21 weeks. Here we set to analyze the ele...

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Bibliographic Details
Main Authors: David Sedmera, Jan Neckar, Jiri Benes, Jana Pospisilova, Jiri Petrak, Kamil Sedlacek, Vojtech Melenovsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Physiology
Subjects:
Hypertrophy
connexin43
conduction velocity
Aorto-caval fistula
autonomic heart innervation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00367/full

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