Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine
The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to...
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doaj-339e2d3a21b5468784790cc94757b9232020-11-25T00:25:08ZengMDPI AGMolecules1420-30492014-09-01199139091393110.3390/molecules190913909molecules190913909Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of FamotidineMahboubeh Razavi0Shaik Nyamathulla1Hamed Karimian2Soheil Zorofchian Moghadamtousi3Mohamed Ibrahim Noordin4Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaBiomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaThe gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements. TKP2 was the optimum formulation as it had a short floating lag time (FLT < 30 s) and more than 98.5% drug release in 12 h. The dissolution data were fitted to popular mathematical models to assess the mechanism of drug release, and the optimum formulation showed a predominant first order release and diffusion mechanism. It was concluded that the TKP2 prepared using tamarind kernel powder:xanthan (4:1) was the optimum formulation with shortest floating lag time and more than 90% release in the determined period of time. http://www.mdpi.com/1420-3049/19/9/13909gastroretentive drug delivery systemfloating matrix tabletsustained releasetamarind seed powdertamarind kernel powder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahboubeh Razavi Shaik Nyamathulla Hamed Karimian Soheil Zorofchian Moghadamtousi Mohamed Ibrahim Noordin |
spellingShingle |
Mahboubeh Razavi Shaik Nyamathulla Hamed Karimian Soheil Zorofchian Moghadamtousi Mohamed Ibrahim Noordin Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine Molecules gastroretentive drug delivery system floating matrix tablet sustained release tamarind seed powder tamarind kernel powder |
author_facet |
Mahboubeh Razavi Shaik Nyamathulla Hamed Karimian Soheil Zorofchian Moghadamtousi Mohamed Ibrahim Noordin |
author_sort |
Mahboubeh Razavi |
title |
Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine |
title_short |
Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine |
title_full |
Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine |
title_fullStr |
Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine |
title_full_unstemmed |
Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine |
title_sort |
hydrogel polysaccharides of tamarind and xanthan to formulate hydrodynamically balanced matrix tablets of famotidine |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-09-01 |
description |
The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements. TKP2 was the optimum formulation as it had a short floating lag time (FLT < 30 s) and more than 98.5% drug release in 12 h. The dissolution data were fitted to popular mathematical models to assess the mechanism of drug release, and the optimum formulation showed a predominant first order release and diffusion mechanism. It was concluded that the TKP2 prepared using tamarind kernel powder:xanthan (4:1) was the optimum formulation with shortest floating lag time and more than 90% release in the determined period of time. |
topic |
gastroretentive drug delivery system floating matrix tablet sustained release tamarind seed powder tamarind kernel powder |
url |
http://www.mdpi.com/1420-3049/19/9/13909 |
work_keys_str_mv |
AT mahboubehrazavi hydrogelpolysaccharidesoftamarindandxanthantoformulatehydrodynamicallybalancedmatrixtabletsoffamotidine AT shaiknyamathulla hydrogelpolysaccharidesoftamarindandxanthantoformulatehydrodynamicallybalancedmatrixtabletsoffamotidine AT hamedkarimian hydrogelpolysaccharidesoftamarindandxanthantoformulatehydrodynamicallybalancedmatrixtabletsoffamotidine AT soheilzorofchianmoghadamtousi hydrogelpolysaccharidesoftamarindandxanthantoformulatehydrodynamicallybalancedmatrixtabletsoffamotidine AT mohamedibrahimnoordin hydrogelpolysaccharidesoftamarindandxanthantoformulatehydrodynamicallybalancedmatrixtabletsoffamotidine |
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1725349852074737664 |