Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report
Neurofibromatosis type 1 (NF1) is a genetic syndrome which typically presents with neurological manifestations. Some of the patients may also present with vasculopathies, among which arterial aneurysms and stenosis are the most common. Deep vein thrombosis (DVT) has rarely been described, and, to th...
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doaj-33a479a978bd40bc94819b9ab4eab6952021-06-28T22:41:18ZengThieme Revinter Publicações Ltda.Brazilian Neurosurgery0103-53552359-59222021-01-01400110711210.1055/s-0040-1722244Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case ReportFernando Guedes0Francisco Torrão1Gabriel E. Sanches2Ana Caroline Siquara-de-Sousa3Arno von Ristow4Paulo Niemeyer Filho5Department of Surgery, Division of Neurosurgery, Hospital Universitário Gaffrée e Guinle, Escola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro (Unirio), Rio de Janeiro, BrazilDepartment of Surgery, Division of Neurosurgery, Hospital Universitário Gaffrée e Guinle, Escola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro (Unirio), Rio de Janeiro, BrazilDepartment of Surgery, Division of Neurosurgery, Hospital Universitário Gaffrée e Guinle, Escola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro (Unirio), Rio de Janeiro, BrazilDepartment of Pathology, Hospital Universitário Antônio Pedro, Faculdade de Medicina, Universidade Federal Fluminense (UFF), Niterói, BrazilVascular and Endovascular Surgery, Pontifícia Universidade Católica do Rio de Janeiro, (PUC-Rio), Rio de Janeiro, BrazilDepartment of Neurosurgery, Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, BrazilNeurofibromatosis type 1 (NF1) is a genetic syndrome which typically presents with neurological manifestations. Some of the patients may also present with vasculopathies, among which arterial aneurysms and stenosis are the most common. Deep vein thrombosis (DVT) has rarely been described, and, to the best of our knowledge, the present is the first report of DVT due to venous compression by a neurofibroma in the setting of NF1. This is the case of a 23-year-old male with NF1 who experienced DVT due to compression of the left posterior tibial veins by a large tumor arising from the tibial nerve. The DVT was acutely treated with enoxaparin and then with rivaroxaban. Two months after the diagnosis, Doppler ultrasonography showed partial recanalization and persistence of the DVT. The patient was then referred to neurosurgery for surgical resection of the tumor. There were no complications during the procedure, and the patient did not present postoperative neurological deficits. The final histopathological diagnosis was of a benign neurofibroma. After one year of follow-up with vascular surgery, the patient presented no more episodes of DVT. In case there is a tumor compressing the deep vessels of the leg and promoting DVT, surgical resection with microsurgical techniques may be curative.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1722244neurofibromatosis 1neurofibromavenous thrombosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fernando Guedes Francisco Torrão Gabriel E. Sanches Ana Caroline Siquara-de-Sousa Arno von Ristow Paulo Niemeyer Filho |
spellingShingle |
Fernando Guedes Francisco Torrão Gabriel E. Sanches Ana Caroline Siquara-de-Sousa Arno von Ristow Paulo Niemeyer Filho Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report Brazilian Neurosurgery neurofibromatosis 1 neurofibroma venous thrombosis |
author_facet |
Fernando Guedes Francisco Torrão Gabriel E. Sanches Ana Caroline Siquara-de-Sousa Arno von Ristow Paulo Niemeyer Filho |
author_sort |
Fernando Guedes |
title |
Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report |
title_short |
Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report |
title_full |
Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report |
title_fullStr |
Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report |
title_full_unstemmed |
Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report |
title_sort |
deep vein thrombosis in the setting of neurofibromatosis type 1: case report |
publisher |
Thieme Revinter Publicações Ltda. |
series |
Brazilian Neurosurgery |
issn |
0103-5355 2359-5922 |
publishDate |
2021-01-01 |
description |
Neurofibromatosis type 1 (NF1) is a genetic syndrome which typically presents with neurological manifestations. Some of the patients may also present with vasculopathies, among which arterial aneurysms and stenosis are the most common. Deep vein thrombosis (DVT) has rarely been described, and, to the best of our knowledge, the present is the first report of DVT due to venous compression by a neurofibroma in the setting of NF1. This is the case of a 23-year-old male with NF1 who experienced DVT due to compression of the left posterior tibial veins by a large tumor arising from the tibial nerve. The DVT was acutely treated with enoxaparin and then with rivaroxaban. Two months after the diagnosis, Doppler ultrasonography showed partial recanalization and persistence of the DVT. The patient was then referred to neurosurgery for surgical resection of the tumor. There were no complications during the procedure, and the patient did not present postoperative neurological deficits. The final histopathological diagnosis was of a benign neurofibroma. After one year of follow-up with vascular surgery, the patient presented no more episodes of DVT. In case there is a tumor compressing the deep vessels of the leg and promoting DVT, surgical resection with microsurgical techniques may be curative. |
topic |
neurofibromatosis 1 neurofibroma venous thrombosis |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1722244 |
work_keys_str_mv |
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