Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway.

Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway.

In daily life, humans are exposed to the extremely low-frequency electromagnetic fields (ELF-EMFs) generated by electric appliances, and public concern is increasing regarding the biological effects of such exposure. Numerous studies have yielded inconsistent results regarding the biological effects...

Full description

Bibliographic Details
Main Authors:	Chao-Ying Huang, Cheng-Wei Chang, Chaang-Ray Chen, Chun-Yu Chuang, Chi-Shiun Chiang, Wun-Yi Shu, Tai-Ching Fan, Ian C Hsu
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4128733?pdf=render

Similar Items

Naphthalimides Induce G2 Arrest Through the ATM-Activated Chk2-Executed Pathway in HCT116 Cells
by: Hong Zhu, et al.
Published: (2009-11-01)

Distinct epidermal keratinocytes respond to extremely low-frequency electromagnetic fields differently.
by: Chao-Ying Huang, et al.
Published: (2014-01-01)

The study of cell survival by exposure of extremely low frequency electromagnetic fields
by: Chaang Ray Chen, et al.
Published: (1999)

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells
by: Iraia García-Santisteban, et al.
Published: (2021-02-01)

Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways
by: Minjie Zhang, et al.
Published: (2021-01-01)

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
by: Christopher Bruhn, et al.
Published: (2020-08-01)

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
by: Anna Di Benedetto, et al.
Published: (2017-08-01)

Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm.
by: Bin Wang, et al.
Published: (2013-01-01)

Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice
by: Qin Luo, et al.
Published: (2018-12-01)

Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors
by: Wang, Wei-Ting
Published: (2014)

Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation
by: Tai-Shan Shen, et al.
Published: (2019-07-01)

Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.
by: Pavel A Nikitin, et al.
Published: (2014-01-01)

XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer
by: Wenjun Wang, et al.
Published: (2017-01-01)

ATM/CHK/p53 Pathway Dependent Chemopreventive and Therapeutic Activity on Lung Cancer by Pterostilbene.
by: Hani Lee, et al.
Published: (2016-01-01)

Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts
by: Amrutha Kizhedathu, et al.
Published: (2020-09-01)

Corrigendum to “XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer”
by: Wenjun Wang, et al.
Published: (2021-01-01)

SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway
by: Xin Nie, et al.
Published: (2019-04-01)

Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin
by: Shi Yandong, et al.
Published: (2012-12-01)

ATM and Chk2 regulate BRCA1 in DNA end-joining repair of double strand breaks
by: Hui-Chun Wang, et al.
Published: (2006)

Activation of Chk2 contributes to baicalein-induced G2/M cell cycle arrest in human ovarian cancer cells
by: Wei-Syun Shao, et al.
Published: (2011)

Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway
by: Linlin Song, et al.
Published: (2018-11-01)

Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide
by: H. Ling, et al.
Published: (2010-03-01)

Regulation of Chk1
by: Calonge Teresa M, et al.
Published: (2009-04-01)

Increases in mitochondrial DNA content and 4977-bp deletion upon ATM/Chk2 checkpoint activation in HeLa cells.
by: Rong Niu, et al.
Published: (2012-01-01)

A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway.
by: Jianhua Gong, et al.
Published: (2018-01-01)

Role of Chk1 and Chk2 in mitotic checkpoint control in vertebrate cells
by: Oehler, Verena
Published: (2008)

Radiation-induced Phosphorylation of Chk1 at S345 is Associated with p53-dependent Cell Cycle Arrest Pathways
by: Hui Tian, et al.
Published: (2002-01-01)

Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction
by: Jennifer P. Ditano, et al.
Published: (2021-03-01)

Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2
by: Arnatchai Maiuthed, et al.
Published: (2018-10-01)

Extremely Low Frequency Electromagnetic Radiation and Health Effects
by: Alpaslan TÜRKKAN, et al.
Published: (2009-08-01)

An Adjustable Extremely Low Frequency Electromagnetic Field Generator
by: Mohammad Mehdi Movahedi, et al.
Published: (2015-03-01)

The effects of extremely low frequency electromagnetic fields on insects
by: Shepherd, Sebastian James
Published: (2018)

Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway
by: Mai Nagasaka, et al.
Published: (2018-06-01)

An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells
by: Luftig Micah, et al.
Published: (2010-10-01)

Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.
by: Jiajie Guo, et al.
Published: (2014-01-01)

The human DNA damage sensor RAD9B affects CHK2-T68 phosphorylation, p21 stability and cell survival in G1
by: Aljohani, Saad Ali
Published: (2016)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
by: Xinfang Yu, et al.
Published: (2020-05-01)

Blocking CHK1 Expression Induces Apoptosis and Abrogates the G2 Checkpoint Mechanism
by: Yan Luo, et al.
Published: (2001-01-01)

Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21
by: Marijn T.M. van Jaarsveld, et al.
Published: (2019-02-01)

Nimbolide Represses the Proliferation, Migration, and Invasion of Bladder Carcinoma Cells via Chk2-Mediated G2/M Phase Cell Cycle Arrest, Altered Signaling Pathways, and Reduced Transcription Factors-Associated MMP-9 Expression
by: Seung-Shick Shin, et al.
Published: (2019-01-01)