B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.

Bibliographic Details
Main Authors:	Benjamin G. Barwick, Christopher D. Scharer, Ryan J. Martinez, Madeline J. Price, Alexander N. Wein, Robert R. Haines, Alexander P. R. Bally, Jacob E. Kohlmeier, Jeremy M. Boss
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04234-4

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spelling	doaj-33af14121bb04d5cbdd45624b424b0e72021-05-11T10:30:00ZengNature Publishing GroupNature Communications2041-17232018-05-019111410.1038/s41467-018-04234-4B cell activation and plasma cell differentiation are inhibited by de novo DNA methylationBenjamin G. Barwick0Christopher D. Scharer1Ryan J. Martinez2Madeline J. Price3Alexander N. Wein4Robert R. Haines5Alexander P. R. Bally6Jacob E. Kohlmeier7Jeremy M. Boss8Department of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDepartment of Microbiology & Immunology, Emory University School of MedicineDNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.https://doi.org/10.1038/s41467-018-04234-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Benjamin G. Barwick Christopher D. Scharer Ryan J. Martinez Madeline J. Price Alexander N. Wein Robert R. Haines Alexander P. R. Bally Jacob E. Kohlmeier Jeremy M. Boss
spellingShingle	Benjamin G. Barwick Christopher D. Scharer Ryan J. Martinez Madeline J. Price Alexander N. Wein Robert R. Haines Alexander P. R. Bally Jacob E. Kohlmeier Jeremy M. Boss B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation Nature Communications
author_facet	Benjamin G. Barwick Christopher D. Scharer Ryan J. Martinez Madeline J. Price Alexander N. Wein Robert R. Haines Alexander P. R. Bally Jacob E. Kohlmeier Jeremy M. Boss
author_sort	Benjamin G. Barwick
title	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_short	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_full	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_fullStr	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_full_unstemmed	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_sort	b cell activation and plasma cell differentiation are inhibited by de novo dna methylation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.
url	https://doi.org/10.1038/s41467-018-04234-4
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B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

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