The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study
This study aimed to investigate the presence of human papillomavirus and Epstein-Barr virus in male lichen sclerosus patients. We extracted DNA from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male LS patients and 30 healthy men and performed real-time PCR test to detect HPV and EB...
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Wolters Kluwer Medknow Publications
2016-01-01
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doaj-33af4f5d235d44c2a555e77d0ed923852020-11-25T00:41:19ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622016-01-0118465065310.4103/1008-682X.160261The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center studyYumeng ZhangQiang FuXiong ZhangThis study aimed to investigate the presence of human papillomavirus and Epstein-Barr virus in male lichen sclerosus patients. We extracted DNA from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male LS patients and 30 healthy men and performed real-time PCR test to detect HPV and EBV. None of the 47 LS patients and 30 healthy men had detectable HPV infection. EBV was detected in 18 LS patients (38.3%) and four healthy men (13.3%), the difference is significant (P < 0.05). Tissue blocks with significant inflammatory reaction tend to have higher EBV load. HPV has no significant relationship with LS. Male LS patients have higher EBV infection rate, but the role of EBV in the pathogenesis of LS needs further investigate.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=4;spage=650;epage=653;aulast=ZhangEpstein-Barr virus; human papillomavirus; lichen sclerosus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yumeng Zhang Qiang Fu Xiong Zhang |
spellingShingle |
Yumeng Zhang Qiang Fu Xiong Zhang The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study Asian Journal of Andrology Epstein-Barr virus; human papillomavirus; lichen sclerosus |
author_facet |
Yumeng Zhang Qiang Fu Xiong Zhang |
author_sort |
Yumeng Zhang |
title |
The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study |
title_short |
The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study |
title_full |
The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study |
title_fullStr |
The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study |
title_full_unstemmed |
The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study |
title_sort |
presence of human papillomavirus and epstein-barr virus in male chinese lichen sclerosus patients: a single center study |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Journal of Andrology |
issn |
1008-682X 1745-7262 |
publishDate |
2016-01-01 |
description |
This study aimed to investigate the presence of human papillomavirus and Epstein-Barr virus in male lichen sclerosus patients. We extracted DNA from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male LS patients and 30 healthy men and performed real-time PCR test to detect HPV and EBV. None of the 47 LS patients and 30 healthy men had detectable HPV infection. EBV was detected in 18 LS patients (38.3%) and four healthy men (13.3%), the difference is significant (P < 0.05). Tissue blocks with significant inflammatory reaction tend to have higher EBV load. HPV has no significant relationship with LS. Male LS patients have higher EBV infection rate, but the role of EBV in the pathogenesis of LS needs further investigate. |
topic |
Epstein-Barr virus; human papillomavirus; lichen sclerosus |
url |
http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=4;spage=650;epage=653;aulast=Zhang |
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