The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women
Abstract Objective To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes. Methods Genotyping and histopathology data from the Chinese Multi-Center Screening Trial (CHIMUST...
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doaj-33b1ceb532b74df1af0a34b8f7a0b83a2021-03-28T11:09:51ZengBMCInfectious Agents and Cancer1750-93782021-03-0116111010.1186/s13027-021-00360-9The prevalence and distribution of human papillomavirus among 10,867 Chinese Han womenChunlei Guo0Hui Du1Jerome L. Belinson2Chun Wang3Xia Huang4Xinfeng Qu5Ruifang Wu6CHIMUST teamDepartment of Obstetrics and Gynecology, Peking University Shenzhen HospitalDepartment of Obstetrics and Gynecology, Peking University Shenzhen HospitalPreventive Oncology International, Inc. Shaker Heights, USA and Cleveland Clinic, Women’s Health InstituteDepartment of Obstetrics and Gynecology, Peking University Shenzhen HospitalDepartment of Obstetrics and Gynecology, Peking University Shenzhen HospitalSanming Project of Medicine in Shenzhen Peking University Shenzhen HospitalDepartment of Obstetrics and Gynecology, Peking University Shenzhen HospitalAbstract Objective To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes. Methods Genotyping and histopathology data from the Chinese Multi-Center Screening Trial (CHIMUST) and its pilot screening trial, from 6 regions across mainland China, were re-analyzed. The data from physician- and self-collected samples from 10,867 Chinese Han women (ages 30–69) were used to determine the prevalence and distribution of hr-HPV and to explore the risk association between hr-HPV genotypes and precancerous lesions. Results 9.2% of the study population tested hr-HPV positive in physician-collected sample. The prevalence varied regionally from the lowest in Guangdong (6.3%) to the highest in Inner Mongolia (13.0%). The most prevalent genotypes found were HPV-52 (21.7%), HPV-16 (19.2%), HPV-58 (15.0%), HPV-39 (8.9%), and HPV-51 (8.2%). The overall odds ratios for CIN2+ and CIN3+ for the presence of HPV-16 was 58.6 (95% CI 39.2–87.5) and, 91.6 (95%CI 54.3–154.6), respectively and remained the highest odds ratio for CIN3+ in all 6 regions. Conclusion Geographical variation exists in the prevalence and distribution of hr-HPV in mainland China. HPV-16/52/58 were the most prevalent genotypes, and HPV-16 had the highest risk for high-grade cervical lesions. Trial registration CHIMUST, Registration number: ChiCTR-EOC-16008456 . Registered 11 May 2016.https://doi.org/10.1186/s13027-021-00360-9Human papillomavirusType-specific prevalenceDistributionriskChinese Han |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chunlei Guo Hui Du Jerome L. Belinson Chun Wang Xia Huang Xinfeng Qu Ruifang Wu CHIMUST team |
spellingShingle |
Chunlei Guo Hui Du Jerome L. Belinson Chun Wang Xia Huang Xinfeng Qu Ruifang Wu CHIMUST team The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women Infectious Agents and Cancer Human papillomavirus Type-specific prevalence Distribution risk Chinese Han |
author_facet |
Chunlei Guo Hui Du Jerome L. Belinson Chun Wang Xia Huang Xinfeng Qu Ruifang Wu CHIMUST team |
author_sort |
Chunlei Guo |
title |
The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women |
title_short |
The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women |
title_full |
The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women |
title_fullStr |
The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women |
title_full_unstemmed |
The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women |
title_sort |
prevalence and distribution of human papillomavirus among 10,867 chinese han women |
publisher |
BMC |
series |
Infectious Agents and Cancer |
issn |
1750-9378 |
publishDate |
2021-03-01 |
description |
Abstract Objective To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes. Methods Genotyping and histopathology data from the Chinese Multi-Center Screening Trial (CHIMUST) and its pilot screening trial, from 6 regions across mainland China, were re-analyzed. The data from physician- and self-collected samples from 10,867 Chinese Han women (ages 30–69) were used to determine the prevalence and distribution of hr-HPV and to explore the risk association between hr-HPV genotypes and precancerous lesions. Results 9.2% of the study population tested hr-HPV positive in physician-collected sample. The prevalence varied regionally from the lowest in Guangdong (6.3%) to the highest in Inner Mongolia (13.0%). The most prevalent genotypes found were HPV-52 (21.7%), HPV-16 (19.2%), HPV-58 (15.0%), HPV-39 (8.9%), and HPV-51 (8.2%). The overall odds ratios for CIN2+ and CIN3+ for the presence of HPV-16 was 58.6 (95% CI 39.2–87.5) and, 91.6 (95%CI 54.3–154.6), respectively and remained the highest odds ratio for CIN3+ in all 6 regions. Conclusion Geographical variation exists in the prevalence and distribution of hr-HPV in mainland China. HPV-16/52/58 were the most prevalent genotypes, and HPV-16 had the highest risk for high-grade cervical lesions. Trial registration CHIMUST, Registration number: ChiCTR-EOC-16008456 . Registered 11 May 2016. |
topic |
Human papillomavirus Type-specific prevalence Distribution risk Chinese Han |
url |
https://doi.org/10.1186/s13027-021-00360-9 |
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