Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population
Abstract Background In this study, the prevalence and persistence of anti-SARS-CoV-2 (severe acute respiratory syndrome-coronavirus) IgG was evaluated in volunteers 90 days after COVID-19 (coronavirus disease 2019) diagnosis by correlating response dynamics with clinical conditions, epidemiological...
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doaj-33c0fe1780c64333a0d9b1fc955ccf152021-05-16T11:07:23ZengBMCBMC Infectious Diseases1471-23342021-05-012111810.1186/s12879-021-06156-xDynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon populationCarlos David Araújo Bichara0Ednelza da Silva Graça Amoras1Gergiane Lopes Vaz2Maria Karoliny da Silva Torres3Maria Alice Freitas Queiroz4Isabella Pinheiro Costa do Amaral5Izaura Maria Vieira Cayres Vallinoto6Cléa Nazaré Carneiro Bichara7Antonio Carlos Rosário Vallinoto8Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA)Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA)Amaral Costa Diagnostic MedicineLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA)Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA)Amaral Costa Diagnostic MedicineLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA)School of Medicine, Center for Biological and Health Sciences, Pará State University (UEPA)Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA)Abstract Background In this study, the prevalence and persistence of anti-SARS-CoV-2 (severe acute respiratory syndrome-coronavirus) IgG was evaluated in volunteers 90 days after COVID-19 (coronavirus disease 2019) diagnosis by correlating response dynamics with clinical conditions, epidemiological characteristics, and disease severity. Methods The study recruited 200 volunteers aged 18 years or older of both sexes diagnosed with COVID-19. Of the 200 volunteers initially selected, the 135 individuals who underwent serological testing for anti-SARS-CoV-2 antibodies on the first visit to the laboratory, were invited to return, after 90 days, and provide a new blood sample for a second assessment of the presence of anti-SARS-CoV-2 IgG antibody. Disease severity and longevity of symptoms were evaluated for each individual and associated with the serological profile. Results Among the 135 individuals who underwent a previous serological test for anti-SARS-CoV-2 antibody, 125 showed reactivity to IgG (92.6%). Of the 125 individuals with detectable IgG in the first test, 87 (69.6%) showed persistence of this antibody after 90 days and 38 (30.4%) lost IgG reactivity in the second evaluation. The frequency of all reported symptoms was higher in individuals who maintained IgG persistence after 90 days of symptoms. Symptom manifestations lasted ≥21 days in the group with a persistent IgG response (39.6%) and ≤ 7 days in the group with a nonpersistent IgG response (50.0%). The length of hospital stay and supplemental oxygen use were higher in individuals with a persistent IgG response. Conclusions The results of the present study show a high frequency of loss of anti-SARS-CoV-2 IgG antibodies within 3 months after COVID-19 diagnosis in the Brazilian Amazon.https://doi.org/10.1186/s12879-021-06156-xCOVID-19SARS-CoV-2IgGAmazon |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos David Araújo Bichara Ednelza da Silva Graça Amoras Gergiane Lopes Vaz Maria Karoliny da Silva Torres Maria Alice Freitas Queiroz Isabella Pinheiro Costa do Amaral Izaura Maria Vieira Cayres Vallinoto Cléa Nazaré Carneiro Bichara Antonio Carlos Rosário Vallinoto |
spellingShingle |
Carlos David Araújo Bichara Ednelza da Silva Graça Amoras Gergiane Lopes Vaz Maria Karoliny da Silva Torres Maria Alice Freitas Queiroz Isabella Pinheiro Costa do Amaral Izaura Maria Vieira Cayres Vallinoto Cléa Nazaré Carneiro Bichara Antonio Carlos Rosário Vallinoto Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population BMC Infectious Diseases COVID-19 SARS-CoV-2 IgG Amazon |
author_facet |
Carlos David Araújo Bichara Ednelza da Silva Graça Amoras Gergiane Lopes Vaz Maria Karoliny da Silva Torres Maria Alice Freitas Queiroz Isabella Pinheiro Costa do Amaral Izaura Maria Vieira Cayres Vallinoto Cléa Nazaré Carneiro Bichara Antonio Carlos Rosário Vallinoto |
author_sort |
Carlos David Araújo Bichara |
title |
Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population |
title_short |
Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population |
title_full |
Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population |
title_fullStr |
Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population |
title_full_unstemmed |
Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population |
title_sort |
dynamics of anti-sars-cov-2 igg antibodies post-covid-19 in a brazilian amazon population |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2021-05-01 |
description |
Abstract Background In this study, the prevalence and persistence of anti-SARS-CoV-2 (severe acute respiratory syndrome-coronavirus) IgG was evaluated in volunteers 90 days after COVID-19 (coronavirus disease 2019) diagnosis by correlating response dynamics with clinical conditions, epidemiological characteristics, and disease severity. Methods The study recruited 200 volunteers aged 18 years or older of both sexes diagnosed with COVID-19. Of the 200 volunteers initially selected, the 135 individuals who underwent serological testing for anti-SARS-CoV-2 antibodies on the first visit to the laboratory, were invited to return, after 90 days, and provide a new blood sample for a second assessment of the presence of anti-SARS-CoV-2 IgG antibody. Disease severity and longevity of symptoms were evaluated for each individual and associated with the serological profile. Results Among the 135 individuals who underwent a previous serological test for anti-SARS-CoV-2 antibody, 125 showed reactivity to IgG (92.6%). Of the 125 individuals with detectable IgG in the first test, 87 (69.6%) showed persistence of this antibody after 90 days and 38 (30.4%) lost IgG reactivity in the second evaluation. The frequency of all reported symptoms was higher in individuals who maintained IgG persistence after 90 days of symptoms. Symptom manifestations lasted ≥21 days in the group with a persistent IgG response (39.6%) and ≤ 7 days in the group with a nonpersistent IgG response (50.0%). The length of hospital stay and supplemental oxygen use were higher in individuals with a persistent IgG response. Conclusions The results of the present study show a high frequency of loss of anti-SARS-CoV-2 IgG antibodies within 3 months after COVID-19 diagnosis in the Brazilian Amazon. |
topic |
COVID-19 SARS-CoV-2 IgG Amazon |
url |
https://doi.org/10.1186/s12879-021-06156-x |
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