Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.

Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.

The platelet receptor CLEC-2 is involved in thrombosis/hemostasis, but its ligand, podoplanin, is expressed only in advanced atherosclerotic lesions. We investigated CLEC-2 ligands in vessel walls. Recombinant CLEC-2 bound to early atherosclerotic lesions and normal arterial walls, co-localizing wit...

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Bibliographic Details
Main Authors: Osamu Inoue, Kazuya Hokamura, Toshiaki Shirai, Makoto Osada, Nagaharu Tsukiji, Kinta Hatakeyama, Kazuo Umemura, Yujiro Asada, Katsue Suzuki-Inoue, Yukio Ozaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4587843?pdf=render

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