Alternative platelet activation pathways and their role in neurodegenerative diseases
Purpose of the review: The study of platelets in the context of neurodegenerative diseases is intensifying, and increasing evidence suggests that platelets may play an important role in the pathogenesis of neurodegenerative disorders. Therefore, we aim to provide a comprehensive overview of the role...
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2021-11-01
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doaj-33c368e56dac4f8fb1d07b71f12f3d462021-10-07T04:24:13ZengElsevierNeurobiology of Disease1095-953X2021-11-01159105512Alternative platelet activation pathways and their role in neurodegenerative diseasesPaula Ferrer-Raventós0Katrin Beyer1Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, SpainDepartment of Pathology, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), 08916 Badalona, Barcelona, Spain; Corresponding author.Purpose of the review: The study of platelets in the context of neurodegenerative diseases is intensifying, and increasing evidence suggests that platelets may play an important role in the pathogenesis of neurodegenerative disorders. Therefore, we aim to provide a comprehensive overview of the role of platelets and their diverse activation pathways in the development of these diseases. Recent findings: Platelets participate in synaptic plasticity, learning, memory, and platelets activated by exercise promote neuronal differentiation in several brain regions. Platelets also contribute to the immune response by modulating their surface protein profile and releasing pro- and anti-inflammatory mediators. In Alzheimer's disease, increased levels of platelet amyloid precursor protein raise the production of amyloid-beta peptides promoting platelet activation, triggering at the same time amyloid-beta fibrillation. In Parkinson's disease, increased platelet α-synuclein is associated with elevated ROS production and mitochondrial dysfunction. Summary: In this review, we revise different platelet activation pathways, those classically involved in hemostasis and wound healing, and alternative activation pathways recently described in the context of neurodegenerative diseases, especially in Alzheimer's disease.http://www.sciencedirect.com/science/article/pii/S0969996121002618PlateletsNeurodegenerative diseasesAlternative platelet activationAlzheimer's diseaseBeta-amyloidParkinson's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paula Ferrer-Raventós Katrin Beyer |
spellingShingle |
Paula Ferrer-Raventós Katrin Beyer Alternative platelet activation pathways and their role in neurodegenerative diseases Neurobiology of Disease Platelets Neurodegenerative diseases Alternative platelet activation Alzheimer's disease Beta-amyloid Parkinson's disease |
author_facet |
Paula Ferrer-Raventós Katrin Beyer |
author_sort |
Paula Ferrer-Raventós |
title |
Alternative platelet activation pathways and their role in neurodegenerative diseases |
title_short |
Alternative platelet activation pathways and their role in neurodegenerative diseases |
title_full |
Alternative platelet activation pathways and their role in neurodegenerative diseases |
title_fullStr |
Alternative platelet activation pathways and their role in neurodegenerative diseases |
title_full_unstemmed |
Alternative platelet activation pathways and their role in neurodegenerative diseases |
title_sort |
alternative platelet activation pathways and their role in neurodegenerative diseases |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2021-11-01 |
description |
Purpose of the review: The study of platelets in the context of neurodegenerative diseases is intensifying, and increasing evidence suggests that platelets may play an important role in the pathogenesis of neurodegenerative disorders. Therefore, we aim to provide a comprehensive overview of the role of platelets and their diverse activation pathways in the development of these diseases. Recent findings: Platelets participate in synaptic plasticity, learning, memory, and platelets activated by exercise promote neuronal differentiation in several brain regions. Platelets also contribute to the immune response by modulating their surface protein profile and releasing pro- and anti-inflammatory mediators. In Alzheimer's disease, increased levels of platelet amyloid precursor protein raise the production of amyloid-beta peptides promoting platelet activation, triggering at the same time amyloid-beta fibrillation. In Parkinson's disease, increased platelet α-synuclein is associated with elevated ROS production and mitochondrial dysfunction. Summary: In this review, we revise different platelet activation pathways, those classically involved in hemostasis and wound healing, and alternative activation pathways recently described in the context of neurodegenerative diseases, especially in Alzheimer's disease. |
topic |
Platelets Neurodegenerative diseases Alternative platelet activation Alzheimer's disease Beta-amyloid Parkinson's disease |
url |
http://www.sciencedirect.com/science/article/pii/S0969996121002618 |
work_keys_str_mv |
AT paulaferrerraventos alternativeplateletactivationpathwaysandtheirroleinneurodegenerativediseases AT katrinbeyer alternativeplateletactivationpathwaysandtheirroleinneurodegenerativediseases |
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