A collagen glucosyltransferase drives lung adenocarcinoma progression in mice
Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-04-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01982-w |
| id |
doaj-33c609a5058f4848b50950a0e6133563 |
|---|---|
| record_format |
Article |
| spelling |
doaj-33c609a5058f4848b50950a0e61335632021-04-25T11:29:37ZengNature Publishing GroupCommunications Biology2399-36422021-04-014111010.1038/s42003-021-01982-wA collagen glucosyltransferase drives lung adenocarcinoma progression in miceHou-Fu Guo0Neus Bota-Rabassedas1Masahiko Terajima2B. Leticia Rodriguez3Don L. Gibbons4Yulong Chen5Priyam Banerjee6Chi-Lin Tsai7Xiaochao Tan8Xin Liu9Jiang Yu10Michal Tokmina-Roszyk11Roma Stawikowska12Gregg B. Fields13Mitchell D. Miller14Xiaoyan Wang15Juhoon Lee16Kevin N. Dalby17Chad J. Creighton18George N. Phillips19John A. Tainer20Mitsuo Yamauchi21Jonathan M. Kurie22Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel HillDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterInstitute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic UniversityInstitute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic UniversityInstitute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic UniversityDepartment of Biosciences, Rice UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDivision of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at AustinDivision of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at AustinDepartment of Medicine, Dan L. Duncan Cancer Center, Baylor College of MedicineDepartment of Biosciences, Rice UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel HillDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterGuo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.https://doi.org/10.1038/s42003-021-01982-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hou-Fu Guo Neus Bota-Rabassedas Masahiko Terajima B. Leticia Rodriguez Don L. Gibbons Yulong Chen Priyam Banerjee Chi-Lin Tsai Xiaochao Tan Xin Liu Jiang Yu Michal Tokmina-Roszyk Roma Stawikowska Gregg B. Fields Mitchell D. Miller Xiaoyan Wang Juhoon Lee Kevin N. Dalby Chad J. Creighton George N. Phillips John A. Tainer Mitsuo Yamauchi Jonathan M. Kurie |
| spellingShingle |
Hou-Fu Guo Neus Bota-Rabassedas Masahiko Terajima B. Leticia Rodriguez Don L. Gibbons Yulong Chen Priyam Banerjee Chi-Lin Tsai Xiaochao Tan Xin Liu Jiang Yu Michal Tokmina-Roszyk Roma Stawikowska Gregg B. Fields Mitchell D. Miller Xiaoyan Wang Juhoon Lee Kevin N. Dalby Chad J. Creighton George N. Phillips John A. Tainer Mitsuo Yamauchi Jonathan M. Kurie A collagen glucosyltransferase drives lung adenocarcinoma progression in mice Communications Biology |
| author_facet |
Hou-Fu Guo Neus Bota-Rabassedas Masahiko Terajima B. Leticia Rodriguez Don L. Gibbons Yulong Chen Priyam Banerjee Chi-Lin Tsai Xiaochao Tan Xin Liu Jiang Yu Michal Tokmina-Roszyk Roma Stawikowska Gregg B. Fields Mitchell D. Miller Xiaoyan Wang Juhoon Lee Kevin N. Dalby Chad J. Creighton George N. Phillips John A. Tainer Mitsuo Yamauchi Jonathan M. Kurie |
| author_sort |
Hou-Fu Guo |
| title |
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_short |
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_full |
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_fullStr |
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_full_unstemmed |
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_sort |
collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-04-01 |
| description |
Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression. |
| url |
https://doi.org/10.1038/s42003-021-01982-w |
| work_keys_str_mv |
AT houfuguo acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT neusbotarabassedas acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT masahikoterajima acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT bleticiarodriguez acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT donlgibbons acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT yulongchen acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT priyambanerjee acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT chilintsai acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT xiaochaotan acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT xinliu acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT jiangyu acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT michaltokminaroszyk acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT romastawikowska acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT greggbfields acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT mitchelldmiller acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT xiaoyanwang acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT juhoonlee acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT kevinndalby acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT chadjcreighton acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT georgenphillips acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT johnatainer acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT mitsuoyamauchi acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT jonathanmkurie acollagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT houfuguo collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT neusbotarabassedas collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT masahikoterajima collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT bleticiarodriguez collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT donlgibbons collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT yulongchen collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT priyambanerjee collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT chilintsai collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT xiaochaotan collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT xinliu collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT jiangyu collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT michaltokminaroszyk collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT romastawikowska collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT greggbfields collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT mitchelldmiller collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT xiaoyanwang collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT juhoonlee collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT kevinndalby collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT chadjcreighton collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT georgenphillips collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT johnatainer collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT mitsuoyamauchi collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice AT jonathanmkurie collagenglucosyltransferasedriveslungadenocarcinomaprogressioninmice |
| _version_ |
1721509689349373952 |