CD38 in Neurodegeneration and Neuroinflammation
Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration and neuroinflammation remains elusive. Yet, CD38...
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doaj-33c61c72ae934127b8512919c3517b692020-11-25T00:19:32ZengMDPI AGCells2073-44092020-02-019247110.3390/cells9020471cells9020471CD38 in Neurodegeneration and NeuroinflammationSerge Guerreiro0Anne-Laure Privat1Laurence Bressac2Damien Toulorge3Encefa, 16 Avenue des Arts, 94100 Saint-Maur-des-Fosses, FranceEncefa, 16 Avenue des Arts, 94100 Saint-Maur-des-Fosses, FranceEncefa, 16 Avenue des Arts, 94100 Saint-Maur-des-Fosses, FranceEncefa, 16 Avenue des Arts, 94100 Saint-Maur-des-Fosses, FranceNeurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration and neuroinflammation remains elusive. Yet, CD38 expression increases as a consequence of aging which is otherwise the primary risk associated with neurodegenerative diseases, and several experimental data demonstrated that CD38 knockout mice are protected from neurodegenerative and neuroinflammatory insults. Moreover, nicotinamide adenine dinucleotide, whose levels are tightly controlled by CD38, is a recognized and potent neuroprotective agent, and NAD supplementation was found to be beneficial against neurodegenerative diseases. The aims of this review are to summarize the physiological role played by CD38 in the brain, present the arguments indicating the involvement of CD38 in neurodegeneration and neuroinflammation, and to discuss these observations in light of CD38 complex biology.https://www.mdpi.com/2073-4409/9/2/471cd38nadneurodegenerationneuroinflammationagingalzheimer’s diseaseparkinson’s diseaseals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Serge Guerreiro Anne-Laure Privat Laurence Bressac Damien Toulorge |
spellingShingle |
Serge Guerreiro Anne-Laure Privat Laurence Bressac Damien Toulorge CD38 in Neurodegeneration and Neuroinflammation Cells cd38 nad neurodegeneration neuroinflammation aging alzheimer’s disease parkinson’s disease als |
author_facet |
Serge Guerreiro Anne-Laure Privat Laurence Bressac Damien Toulorge |
author_sort |
Serge Guerreiro |
title |
CD38 in Neurodegeneration and Neuroinflammation |
title_short |
CD38 in Neurodegeneration and Neuroinflammation |
title_full |
CD38 in Neurodegeneration and Neuroinflammation |
title_fullStr |
CD38 in Neurodegeneration and Neuroinflammation |
title_full_unstemmed |
CD38 in Neurodegeneration and Neuroinflammation |
title_sort |
cd38 in neurodegeneration and neuroinflammation |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-02-01 |
description |
Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration and neuroinflammation remains elusive. Yet, CD38 expression increases as a consequence of aging which is otherwise the primary risk associated with neurodegenerative diseases, and several experimental data demonstrated that CD38 knockout mice are protected from neurodegenerative and neuroinflammatory insults. Moreover, nicotinamide adenine dinucleotide, whose levels are tightly controlled by CD38, is a recognized and potent neuroprotective agent, and NAD supplementation was found to be beneficial against neurodegenerative diseases. The aims of this review are to summarize the physiological role played by CD38 in the brain, present the arguments indicating the involvement of CD38 in neurodegeneration and neuroinflammation, and to discuss these observations in light of CD38 complex biology. |
topic |
cd38 nad neurodegeneration neuroinflammation aging alzheimer’s disease parkinson’s disease als |
url |
https://www.mdpi.com/2073-4409/9/2/471 |
work_keys_str_mv |
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