Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients

Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients

Senescent T cells have been described during aging, chronic infections, and cancer; however, a comprehensive study of the phenotype, function, and transcriptional program of this T cell population in breast cancer (BC) patients is missing. Compared to healthy donors (HDs), BC patients exhibit an acc...

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Bibliographic Details
Main Authors:	Maria C. Ramello, Nicolás G. Núñez, Jimena Tosello Boari, Sabrina N. Bossio, Fernando P. Canale, Carolina Abrate, Nicolas Ponce, Andrés Del Castillo, Marta Ledesma, Sophie Viel, Wilfrid Richer, Christine Sedlik, Carolina Tiraboschi, Marcos Muñoz, Daniel Compagno, Adriana Gruppi, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Immunology
Subjects:	senescent T cells polyfunctional T cells breast cancer KLRG-1 CD57 cytotoxic CD4+T cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.713132/full

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