Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus
Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in t...
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doaj-33d4438008a7403c85b3b6e8b4bf4fdc2020-11-25T00:34:53ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-04-011310.3389/fncel.2019.00131435460Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior ColliculusYun LiuGuodong ZhangHaipeng YuHe LiJinxing WeiZhongju XiaoIntensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of intensity encoding. Although previous researchers have hinted at the importance of inhibitory effects on the formation of non-monotonic neurons, the specific underlying synaptic mechanisms in the ICC are still unclear. Therefore, we applied the in vivo whole-cell voltage-clamp technique to record the excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) in the ICC neurons, and compared the effects of excitation and inhibition on the membrane potential outputs. We found that non-monotonic neuron responses could not only be inherited from the lower nucleus but also be created in the ICC. By integrating with a relatively weak IPSC, approximately 35% of the monotonic excitatory inputs remained in the ICC. In the remaining cases, monotonic excitatory inputs were reshaped into non-monotonic outputs by the dominating inhibition at high intensity, which also enhanced the non-monotonic nature of the non-monotonic excitatory inputs.https://www.frontiersin.org/article/10.3389/fncel.2019.00131/fullthe central nucleus of the inferior colliculusintensity-tuned neuronsnon-monotonic neuronsmonotonic neuronsin vivo whole-cell recordingsynaptic currents |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yun Liu Guodong Zhang Haipeng Yu He Li Jinxing Wei Zhongju Xiao |
spellingShingle |
Yun Liu Guodong Zhang Haipeng Yu He Li Jinxing Wei Zhongju Xiao Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus Frontiers in Cellular Neuroscience the central nucleus of the inferior colliculus intensity-tuned neurons non-monotonic neurons monotonic neurons in vivo whole-cell recording synaptic currents |
author_facet |
Yun Liu Guodong Zhang Haipeng Yu He Li Jinxing Wei Zhongju Xiao |
author_sort |
Yun Liu |
title |
Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus |
title_short |
Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus |
title_full |
Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus |
title_fullStr |
Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus |
title_full_unstemmed |
Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus |
title_sort |
robust and intensity-dependent synaptic inhibition underlies the generation of non-monotonic neurons in the mouse inferior colliculus |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2019-04-01 |
description |
Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of intensity encoding. Although previous researchers have hinted at the importance of inhibitory effects on the formation of non-monotonic neurons, the specific underlying synaptic mechanisms in the ICC are still unclear. Therefore, we applied the in vivo whole-cell voltage-clamp technique to record the excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) in the ICC neurons, and compared the effects of excitation and inhibition on the membrane potential outputs. We found that non-monotonic neuron responses could not only be inherited from the lower nucleus but also be created in the ICC. By integrating with a relatively weak IPSC, approximately 35% of the monotonic excitatory inputs remained in the ICC. In the remaining cases, monotonic excitatory inputs were reshaped into non-monotonic outputs by the dominating inhibition at high intensity, which also enhanced the non-monotonic nature of the non-monotonic excitatory inputs. |
topic |
the central nucleus of the inferior colliculus intensity-tuned neurons non-monotonic neurons monotonic neurons in vivo whole-cell recording synaptic currents |
url |
https://www.frontiersin.org/article/10.3389/fncel.2019.00131/full |
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