The correlation of serum sCD40 and its ligand contents with renal injury in patients with preeclampsia
Objective: To study the correlation of serum sCD40 and its ligand contents with renal injury in patients with preeclampsia. Methods: 68 patients with preeclampsia who were treated in our hospital between May 2012 and January 2016 were collected and divided into mild preeclampsia group (n=38) and...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-04-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201707/22.pdf |
Summary: | Objective: To study the correlation of serum sCD40 and its ligand contents with renal injury
in patients with preeclampsia. Methods: 68 patients with preeclampsia who were treated
in our hospital between May 2012 and January 2016 were collected and divided into mild
preeclampsia group (n=38) and severe preeclampsia group (n=30), and 57 health pregnant
women who received antenatal care in our hospital during the same period were selected as
control group. ELISA was used to detect serum contents of soluble CD40 (sCD40) and its
ligand (sCD40L) as well as renal injury indexes; automatic biochemical analyzer was used to
test the contents of renal function indexes; color Doppler diasonograph was used to detect renal
aortal hemodynamic parameters. Results: Serum sCD40, sCD40L, BUN, β2-MG, Scr and
Cys C contents as well as urine KIM-1 and NGAL contents of severe preeclampsia group and
mild preeclampsia group were significantly higher than those of control group (P<0.05), and serum
sCD40, sCD40L, blood urea nitrogen (BUN), β2 microglobulin (β2-MG), serum creatinine
(Scr) and cystatin C (Cys C) contents as well as urine kidney injury molecule 1 (KIM-1) and
neutrophil gelatinase-associated lipocalin (NGAL) contents of severe preeclampsia group
were significantly higher than those of mild preeclampsia group (P<0.05); blood flow peak
acceleration time (AT) and resistance index (RI) levels of severe preeclampsia group and mild
preeclampsia group were higher than those of control group (P<0.05) while peak systolic
flow velocity (Vs) and end-diastolic flow velocity (Vd) levels were lower than those of control
group (P<0.05), and the AT and RI levels of severe preeclampsia group were higher than
those of mild preeclampsia group (P<0.05) while Vs and Vd levels were lower than those
of mild preeclampsia group (P<0.05); serum sCD40 and sCD40L contents in patients with
preeclampsia were correlated with the renal injury severity. Conclusion: Serum sCD40 and
sCD40L contents significantly increase in patients with preeclampsia, are correlated with
patients’ renal injury, and can be used to evaluate the degree of renal injury. |
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ISSN: | 1007-1237 1007-1237 |