The correlation of serum sCD40 and its ligand contents with renal injury in patients with preeclampsia

• Main Authors: Zuo-Mei Shang, Wei Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Preeclampsia Soluble CD40 Soluble CD40 ligand Renal injury
• Online Access: http://www.hnykdxxb.com/PDF/201707/22.pdf

Objective: To study the correlation of serum sCD40 and its ligand contents with renal injury in patients with preeclampsia. Methods: 68 patients with preeclampsia who were treated in our hospital between May 2012 and January 2016 were collected and divided into mild preeclampsia group (n=38) and severe preeclampsia group (n=30), and 57 health pregnant women who received antenatal care in our hospital during the same period were selected as control group. ELISA was used to detect serum contents of soluble CD40 (sCD40) and its ligand (sCD40L) as well as renal injury indexes; automatic biochemical analyzer was used to test the contents of renal function indexes; color Doppler diasonograph was used to detect renal aortal hemodynamic parameters. Results: Serum sCD40, sCD40L, BUN, β2-MG, Scr and Cys C contents as well as urine KIM-1 and NGAL contents of severe preeclampsia group and mild preeclampsia group were significantly higher than those of control group (P＜0.05), and serum sCD40, sCD40L, blood urea nitrogen (BUN), β2 microglobulin (β2-MG), serum creatinine (Scr) and cystatin C (Cys C) contents as well as urine kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) contents of severe preeclampsia group were significantly higher than those of mild preeclampsia group (P＜0.05); blood flow peak acceleration time (AT) and resistance index (RI) levels of severe preeclampsia group and mild preeclampsia group were higher than those of control group (P＜0.05) while peak systolic flow velocity (Vs) and end-diastolic flow velocity (Vd) levels were lower than those of control group (P＜0.05), and the AT and RI levels of severe preeclampsia group were higher than those of mild preeclampsia group (P＜0.05) while Vs and Vd levels were lower than those of mild preeclampsia group (P＜0.05); serum sCD40 and sCD40L contents in patients with preeclampsia were correlated with the renal injury severity. Conclusion: Serum sCD40 and sCD40L contents significantly increase in patients with preeclampsia, are correlated with patients’ renal injury, and can be used to evaluate the degree of renal injury.