Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya)
The aim of this research was to determine the toxic effect of Anredera cordifolia leaf extract on the Cavia cobaya liver which was evaluated by the histopathological examination of liver tissue. The materials used were 8 female guinea pigs 2.5 months old that were divided into 4 groups by simple ran...
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doaj-33d9b39fc4cc491e9b7c06ff04876b3d2020-11-25T03:05:29ZengUniversitas Gadjah MadaBuletin Peternakan0126-44002407-876X2019-05-0143210.21059/buletinpeternak.v43i2.3948723957Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya)Dwi Wijayanti0Edy Kurnianto1Enny Tantini Setiatin2Department of Animal Science, Faculty of Agriculture, Perjuangan University of Tasikmalaya, Tasikmalaya, 46115, IndonesiaDepartment of Animal Science, Faculty of Animal and Agricultural Sciences, Diponegoro University, Semarang, 50275, IndonesiaDepartment of Animal Science, Faculty of Animal and Agricultural Sciences, Diponegoro University, Semarang, 50275, IndonesiaThe aim of this research was to determine the toxic effect of Anredera cordifolia leaf extract on the Cavia cobaya liver which was evaluated by the histopathological examination of liver tissue. The materials used were 8 female guinea pigs 2.5 months old that were divided into 4 groups by simple random sampling, each treatment was given to 2 female C. cobaya. Treatments given were 0, 10, 50 and 90 mg of A. cordifolia leaf extract/head, designated as T0, T1, T2 and T3, respectively. Materials were given treatment daily as long as 10 days prepartum. All of the guinea pigs were slaughtered at day 11, and the liver were taken to examined their histopathological changes. Each of the liver tissues were processed by paraffin block-embedded and hematoxylin eosin (HE) staining method. The results of this study indicate the presence of albuminosa degeneration or mild degeneration (DH +) from group control and hydropic degeneration or moderate degeneration (DH ++) in all treatment groups and the weight of C. cobaya liver which was given an extract of A. cordifolia 50 mg/head was not significantly different from the control but was significantly different from 10 and 90 mg/head. The conclusion was Binahong's (A. cordifolia) leaves extract up to the dosage 90 mg/head had no significantly toxicity effect on the liver of guinea pigs (C. cobaya).https://jurnal.ugm.ac.id/buletinpeternakan/article/view/39487a. cordifoliaguinea pigsliver, toxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dwi Wijayanti Edy Kurnianto Enny Tantini Setiatin |
spellingShingle |
Dwi Wijayanti Edy Kurnianto Enny Tantini Setiatin Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya) Buletin Peternakan a. cordifolia guinea pigs liver, toxicity |
author_facet |
Dwi Wijayanti Edy Kurnianto Enny Tantini Setiatin |
author_sort |
Dwi Wijayanti |
title |
Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya) |
title_short |
Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya) |
title_full |
Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya) |
title_fullStr |
Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya) |
title_full_unstemmed |
Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya) |
title_sort |
toxicity effect by binahong (anredera cordifolia) leaf extract in histopathology and liver weight of guinea pigs (cavia cobaya) |
publisher |
Universitas Gadjah Mada |
series |
Buletin Peternakan |
issn |
0126-4400 2407-876X |
publishDate |
2019-05-01 |
description |
The aim of this research was to determine the toxic effect of Anredera cordifolia leaf extract on the Cavia cobaya liver which was evaluated by the histopathological examination of liver tissue. The materials used were 8 female guinea pigs 2.5 months old that were divided into 4 groups by simple random sampling, each treatment was given to 2 female C. cobaya. Treatments given were 0, 10, 50 and 90 mg of A. cordifolia leaf extract/head, designated as T0, T1, T2 and T3, respectively. Materials were given treatment daily as long as 10 days prepartum. All of the guinea pigs were slaughtered at day 11, and the liver were taken to examined their histopathological changes. Each of the liver tissues were processed by paraffin block-embedded and hematoxylin eosin (HE) staining method. The results of this study indicate the presence of albuminosa degeneration or mild degeneration (DH +) from group control and hydropic degeneration or moderate degeneration (DH ++) in all treatment groups and the weight of C. cobaya liver which was given an extract of A. cordifolia 50 mg/head was not significantly different from the control but was significantly different from 10 and 90 mg/head. The conclusion was Binahong's (A. cordifolia) leaves extract up to the dosage 90 mg/head had no significantly toxicity effect on the liver of guinea pigs (C. cobaya). |
topic |
a. cordifolia guinea pigs liver, toxicity |
url |
https://jurnal.ugm.ac.id/buletinpeternakan/article/view/39487 |
work_keys_str_mv |
AT dwiwijayanti toxicityeffectbybinahonganrederacordifolialeafextractinhistopathologyandliverweightofguineapigscaviacobaya AT edykurnianto toxicityeffectbybinahonganrederacordifolialeafextractinhistopathologyandliverweightofguineapigscaviacobaya AT ennytantinisetiatin toxicityeffectbybinahonganrederacordifolialeafextractinhistopathologyandliverweightofguineapigscaviacobaya |
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