Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure
Sarcopenia represents a major health burden in industrialized country by reducing substantially the quality of life. Indeed, it is characterized by a progressive and generalized loss of muscle mass and function, leading to an increased risk of adverse outcomes and hospitalizations. Several factors a...
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doaj-33e0d4f8135f4a62b5d38ba6702f06fc2021-07-13T06:54:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.694217694217Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle FailureOlga Maria Nardone0Roberto de Sire1Valentina Petito2Anna Testa3Guido Villani4Franco Scaldaferri5Fabiana Castiglione6Gastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, ItalyGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, ItalyDepartment of Medicine and Translational Surgery, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, University Cattolica del Sacro Cuore, Rome, ItalyGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, ItalyGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, ItalyDepartment of Medicine and Translational Surgery, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, University Cattolica del Sacro Cuore, Rome, ItalyGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, ItalySarcopenia represents a major health burden in industrialized country by reducing substantially the quality of life. Indeed, it is characterized by a progressive and generalized loss of muscle mass and function, leading to an increased risk of adverse outcomes and hospitalizations. Several factors are involved in the pathogenesis of sarcopenia, such as aging, inflammation, mitochondrial dysfunction, and insulin resistance. Recently, it has been reported that more than one third of inflammatory bowel disease (IBD) patients suffered from sarcopenia. Notably, the role of gut microbiota (GM) in developing muscle failure in IBD patient is a matter of increasing interest. It has been hypothesized that gut dysbiosis, that typically characterizes IBD, might alter the immune response and host metabolism, promoting a low-grade inflammation status able to up-regulate several molecular pathways related to sarcopenia. Therefore, we aim to describe the basis of IBD-related sarcopenia and provide the rationale for new potential therapeutic targets that may regulate the gut-muscle axis in IBD patients.https://www.frontiersin.org/articles/10.3389/fimmu.2021.694217/fullIBDsarcopeniagut-muscle axisgut microbiotaprobioticsinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Olga Maria Nardone Roberto de Sire Valentina Petito Anna Testa Guido Villani Franco Scaldaferri Fabiana Castiglione |
spellingShingle |
Olga Maria Nardone Roberto de Sire Valentina Petito Anna Testa Guido Villani Franco Scaldaferri Fabiana Castiglione Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure Frontiers in Immunology IBD sarcopenia gut-muscle axis gut microbiota probiotics inflammation |
author_facet |
Olga Maria Nardone Roberto de Sire Valentina Petito Anna Testa Guido Villani Franco Scaldaferri Fabiana Castiglione |
author_sort |
Olga Maria Nardone |
title |
Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure |
title_short |
Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure |
title_full |
Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure |
title_fullStr |
Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure |
title_full_unstemmed |
Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure |
title_sort |
inflammatory bowel diseases and sarcopenia: the role of inflammation and gut microbiota in the development of muscle failure |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-07-01 |
description |
Sarcopenia represents a major health burden in industrialized country by reducing substantially the quality of life. Indeed, it is characterized by a progressive and generalized loss of muscle mass and function, leading to an increased risk of adverse outcomes and hospitalizations. Several factors are involved in the pathogenesis of sarcopenia, such as aging, inflammation, mitochondrial dysfunction, and insulin resistance. Recently, it has been reported that more than one third of inflammatory bowel disease (IBD) patients suffered from sarcopenia. Notably, the role of gut microbiota (GM) in developing muscle failure in IBD patient is a matter of increasing interest. It has been hypothesized that gut dysbiosis, that typically characterizes IBD, might alter the immune response and host metabolism, promoting a low-grade inflammation status able to up-regulate several molecular pathways related to sarcopenia. Therefore, we aim to describe the basis of IBD-related sarcopenia and provide the rationale for new potential therapeutic targets that may regulate the gut-muscle axis in IBD patients. |
topic |
IBD sarcopenia gut-muscle axis gut microbiota probiotics inflammation |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.694217/full |
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