Regulation of the Germinal Center Response

Regulation of the Germinal Center Response

The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection. Within the GC, B cells undergo somatic mutation of the genes encoding their B...

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Bibliographic Details
Main Authors: Marisa Stebegg, Saumya D. Kumar, Alyssa Silva-Cayetano, Valter R. Fonseca, Michelle A. Linterman, Luis Graca
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
germinal center (GC)
Tfr cell
Tfh cell
immuneregulation
humoral responses
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02469/full

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