Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
Nunzia Nocerino,1 Andrea Fulgione,1 Marco Iannaccone,1 Laura Tomasetta,1 Flora Ianniello,1 Francesca Martora,1 Marco Lelli,2 Norberto Roveri,2 Federico Capuano,3 Rosanna Capparelli1 1Department of Agriculture Special Biotechnology Center Federico II, CeBIOTEC Biotechnology, University of Naples Fed...
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Dove Medical Press
2014-03-01
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doaj-33eab46c792c4f5196953dfd20c968712020-11-24T20:43:09ZengDove Medical PressInternational Journal of Nanomedicine1178-20132014-03-012014Issue 11175118416017Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystalsNocerino NFulgione AIannaccone MTomasetta LIanniello FMartora FLelli MRoveri NCapuano FCapparelli R Nunzia Nocerino,1 Andrea Fulgione,1 Marco Iannaccone,1 Laura Tomasetta,1 Flora Ianniello,1 Francesca Martora,1 Marco Lelli,2 Norberto Roveri,2 Federico Capuano,3 Rosanna Capparelli1 1Department of Agriculture Special Biotechnology Center Federico II, CeBIOTEC Biotechnology, University of Naples Federico II, Naples, 2Department of Chemistry, G Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, 3Department of Food Inspection IZS ME, Naples, Italy Abstract: The emergence of bacterial strains resistant to antibiotics is a general public health problem. Progress in developing new molecules with antimicrobial properties has been made. In this study, we evaluated the biological activity of a hybrid nanocomposite composed of synthetic biomimetic hydroxyapatite surface-functionalized by lactoferrin (LF-HA). We evaluated the antimicrobial, anti-inflammatory, and antioxidant properties of LF-HA and found that the composite was active against both Gram-positive and Gram-negative bacteria, and that it modulated proinflammatory and anti-inflammatory responses and enhanced antioxidant properties as compared with LF alone. These results indicate the possibility of using LF-HA as an antimicrobial system and biomimetic hydroxyapatite as a candidate for innovative biomedical applications. Keywords: lactoferrin, hydroxyapatite nanocrystals, biomimetism, biological activity, drug deliveryhttp://www.dovepress.com/biological-activity-of-lactoferrin-functionalized-biomimetic-hydroxyap-a16017 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nocerino N Fulgione A Iannaccone M Tomasetta L Ianniello F Martora F Lelli M Roveri N Capuano F Capparelli R |
spellingShingle |
Nocerino N Fulgione A Iannaccone M Tomasetta L Ianniello F Martora F Lelli M Roveri N Capuano F Capparelli R Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals International Journal of Nanomedicine |
author_facet |
Nocerino N Fulgione A Iannaccone M Tomasetta L Ianniello F Martora F Lelli M Roveri N Capuano F Capparelli R |
author_sort |
Nocerino N |
title |
Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals |
title_short |
Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals |
title_full |
Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals |
title_fullStr |
Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals |
title_full_unstemmed |
Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals |
title_sort |
biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2014-03-01 |
description |
Nunzia Nocerino,1 Andrea Fulgione,1 Marco Iannaccone,1 Laura Tomasetta,1 Flora Ianniello,1 Francesca Martora,1 Marco Lelli,2 Norberto Roveri,2 Federico Capuano,3 Rosanna Capparelli1 1Department of Agriculture Special Biotechnology Center Federico II, CeBIOTEC Biotechnology, University of Naples Federico II, Naples, 2Department of Chemistry, G Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, 3Department of Food Inspection IZS ME, Naples, Italy Abstract: The emergence of bacterial strains resistant to antibiotics is a general public health problem. Progress in developing new molecules with antimicrobial properties has been made. In this study, we evaluated the biological activity of a hybrid nanocomposite composed of synthetic biomimetic hydroxyapatite surface-functionalized by lactoferrin (LF-HA). We evaluated the antimicrobial, anti-inflammatory, and antioxidant properties of LF-HA and found that the composite was active against both Gram-positive and Gram-negative bacteria, and that it modulated proinflammatory and anti-inflammatory responses and enhanced antioxidant properties as compared with LF alone. These results indicate the possibility of using LF-HA as an antimicrobial system and biomimetic hydroxyapatite as a candidate for innovative biomedical applications. Keywords: lactoferrin, hydroxyapatite nanocrystals, biomimetism, biological activity, drug delivery |
url |
http://www.dovepress.com/biological-activity-of-lactoferrin-functionalized-biomimetic-hydroxyap-a16017 |
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