Osseointegration of titanium implants with a novel silver coating under dynamic loading
Postoperative implant-associated infections are a severe complication in orthopaedics and trauma surgery. To address this problem, a novel implant coating was recently developed, which allows for the release of low concentrations of bactericidal silver. For an intended use on load-bearing endoprosth...
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AO Research Institute Davos
2020-06-01
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doaj-33ee00203bef47208826b5bff3e415be2020-11-25T02:53:43Zeng AO Research Institute DavosEuropean Cells & Materials1473-22622020-06-013924925910.22203/eCM.v039a16 Osseointegration of titanium implants with a novel silver coating under dynamic loadingS Stein0https://orcid.org/0000-0003-0874-8577L Kruck1D Warnecke2 A Seitz3L Dürselen4A Ignatius5Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, GermanyInstitute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, GermanyInstitute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, GermanyInstitute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, GermanyInstitute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, GermanyInstitute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, GermanyPostoperative implant-associated infections are a severe complication in orthopaedics and trauma surgery. To address this problem, a novel implant coating was recently developed, which allows for the release of low concentrations of bactericidal silver. For an intended use on load-bearing endoprostheses, stable bone integration is required. The aim of the present study was to evaluate the biocompatibility and osseointegration of titanium implants with the novel coating in a mechanically loaded bone-defect model in sheep. Silver-coated devices were implanted into weight-bearing and non-weight-bearing tibial and femoral bone defects whereas, in the control group, uncoated titanium implants were inserted. The bony integration of the implants was assessed mechanically and histologically after 6 months. Silver concentrations were assessed in peripheral blood, liver, kidney and local draining lymph nodes as well as at the implantation site. After 6 months, shear strength at the interface and bone apposition to the implant surface were not significantly different between coated and uncoated devices. Mechanical loading reduced bony integration independently of the coating. Silver content at the implantation site was larger in the group with silver-coated implants, yet it remained below toxic levels and no cytotoxic side effects were observed. Concluding, the novel antibacterial silver coating did not negatively influence bone regeneration or implant integration under mechanically unloaded and even loaded conditions, suggesting that the silver coating might be suitable for orthopaedic load-bearing implants, including endoprostheses.https://www.ecmjournal.org/papers/vol039/pdf/v039a16.pdfsilverantibacterial coatingsorthopaedic implantsload-bearing implantsperiprosthetic infectionspostoperative infections. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S Stein L Kruck D Warnecke A Seitz L Dürselen A Ignatius |
spellingShingle |
S Stein L Kruck D Warnecke A Seitz L Dürselen A Ignatius Osseointegration of titanium implants with a novel silver coating under dynamic loading European Cells & Materials silver antibacterial coatings orthopaedic implants load-bearing implants periprosthetic infections postoperative infections. |
author_facet |
S Stein L Kruck D Warnecke A Seitz L Dürselen A Ignatius |
author_sort |
S Stein |
title |
Osseointegration of titanium implants with a novel silver coating under dynamic loading |
title_short |
Osseointegration of titanium implants with a novel silver coating under dynamic loading |
title_full |
Osseointegration of titanium implants with a novel silver coating under dynamic loading |
title_fullStr |
Osseointegration of titanium implants with a novel silver coating under dynamic loading |
title_full_unstemmed |
Osseointegration of titanium implants with a novel silver coating under dynamic loading |
title_sort |
osseointegration of titanium implants with a novel silver coating under dynamic loading |
publisher |
AO Research Institute Davos |
series |
European Cells & Materials |
issn |
1473-2262 |
publishDate |
2020-06-01 |
description |
Postoperative implant-associated infections are a severe complication in orthopaedics and trauma surgery. To address this problem, a novel implant coating was recently developed, which allows for the release of low concentrations of bactericidal silver. For an intended use on load-bearing endoprostheses, stable bone integration is required. The aim of the present study was to evaluate the biocompatibility and osseointegration of titanium implants with the novel coating in a mechanically loaded bone-defect model in sheep.
Silver-coated devices were implanted into weight-bearing and non-weight-bearing tibial and femoral bone defects whereas, in the control group, uncoated titanium implants were inserted. The bony integration of the implants was assessed mechanically and histologically after 6 months. Silver concentrations were assessed in peripheral blood, liver, kidney and local draining lymph nodes as well as at the implantation site.
After 6 months, shear strength at the interface and bone apposition to the implant surface were not significantly different between coated and uncoated devices. Mechanical loading reduced bony integration independently of the coating. Silver content at the implantation site was larger in the group with silver-coated implants, yet it remained below toxic levels and no cytotoxic side effects were observed.
Concluding, the novel antibacterial silver coating did not negatively influence bone regeneration or implant integration under mechanically unloaded and even loaded conditions, suggesting that the silver coating might be suitable for orthopaedic load-bearing implants, including endoprostheses. |
topic |
silver antibacterial coatings orthopaedic implants load-bearing implants periprosthetic infections postoperative infections. |
url |
https://www.ecmjournal.org/papers/vol039/pdf/v039a16.pdf |
work_keys_str_mv |
AT sstein osseointegrationoftitaniumimplantswithanovelsilvercoatingunderdynamicloading AT lkruck osseointegrationoftitaniumimplantswithanovelsilvercoatingunderdynamicloading AT dwarnecke osseointegrationoftitaniumimplantswithanovelsilvercoatingunderdynamicloading AT aseitz osseointegrationoftitaniumimplantswithanovelsilvercoatingunderdynamicloading AT ldurselen osseointegrationoftitaniumimplantswithanovelsilvercoatingunderdynamicloading AT aignatius osseointegrationoftitaniumimplantswithanovelsilvercoatingunderdynamicloading |
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