Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report
A 73-year-old male underwent transurethral resection of a bladder tumor in August 2010 and April 2011. Pathological examination revealed urothelial carcinoma. After the surgery, chemotherapy and intravesical Bacillus Calmette-Guerin instillation were performed. In September 2014, he once again under...
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doaj-33f801b3d82640bb9d4a88e812544fc42020-11-24T23:13:43ZengKarger PublishersCase Reports in Oncology1662-65752016-11-019378679110.1159/000452945452945Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case ReportKento MorozumiShunichi NamikiTakashi KudoMasataka AizawaNaomasa IoritaniKazuhiro SakamotoYasuhiro NakamuraA 73-year-old male underwent transurethral resection of a bladder tumor in August 2010 and April 2011. Pathological examination revealed urothelial carcinoma. After the surgery, chemotherapy and intravesical Bacillus Calmette-Guerin instillation were performed. In September 2014, he once again underwent transurethral resection of the bladder tumor for recurrence, and was again diagnosed with urothelial carcinoma, pT2, by pathological examination. After neoadjuvant chemotherapy, radical cystectomy for tumor recurrence was performed. Pathological examination at this time revealed small cell carcinoma, pT3N0. It is rare for urothelial carcinoma to change to small cell carcinoma, and the mechanism and cause of this change are still unknown. In this case report, we discuss what causes small cell carcinoma of the urinary bladder and review the literature regarding its origin.http://www.karger.com/Article/FullText/452945Small cell carcinomaChemotherapyTransdifferentiationUrinary bladderBacillus Calmette-Guerin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kento Morozumi Shunichi Namiki Takashi Kudo Masataka Aizawa Naomasa Ioritani Kazuhiro Sakamoto Yasuhiro Nakamura |
spellingShingle |
Kento Morozumi Shunichi Namiki Takashi Kudo Masataka Aizawa Naomasa Ioritani Kazuhiro Sakamoto Yasuhiro Nakamura Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report Case Reports in Oncology Small cell carcinoma Chemotherapy Transdifferentiation Urinary bladder Bacillus Calmette-Guerin |
author_facet |
Kento Morozumi Shunichi Namiki Takashi Kudo Masataka Aizawa Naomasa Ioritani Kazuhiro Sakamoto Yasuhiro Nakamura |
author_sort |
Kento Morozumi |
title |
Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report |
title_short |
Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report |
title_full |
Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report |
title_fullStr |
Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report |
title_full_unstemmed |
Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report |
title_sort |
transdifferentiation of small cell carcinoma of the urinary bladder from urothelial carcinoma after transurethral resection of a bladder tumor, intravesical bacillus calmette-guerin instillation, and chemotherapy: a case report |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2016-11-01 |
description |
A 73-year-old male underwent transurethral resection of a bladder tumor in August 2010 and April 2011. Pathological examination revealed urothelial carcinoma. After the surgery, chemotherapy and intravesical Bacillus Calmette-Guerin instillation were performed. In September 2014, he once again underwent transurethral resection of the bladder tumor for recurrence, and was again diagnosed with urothelial carcinoma, pT2, by pathological examination. After neoadjuvant chemotherapy, radical cystectomy for tumor recurrence was performed. Pathological examination at this time revealed small cell carcinoma, pT3N0. It is rare for urothelial carcinoma to change to small cell carcinoma, and the mechanism and cause of this change are still unknown. In this case report, we discuss what causes small cell carcinoma of the urinary bladder and review the literature regarding its origin. |
topic |
Small cell carcinoma Chemotherapy Transdifferentiation Urinary bladder Bacillus Calmette-Guerin |
url |
http://www.karger.com/Article/FullText/452945 |
work_keys_str_mv |
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