Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kuni...
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doaj-33fd3e1cadbc437ab227bf23a70165282020-11-25T00:00:41ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882017-05-01710.3389/fcimb.2017.00216263021Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen InteractionJindřich Chmelař0Jan Kotál1Jan Kotál2Helena Langhansová3Helena Langhansová4Michail Kotsyfakis5Faculty of Science, University of South Bohemia in České BudějoviceČeské Budějovice, CzechiaFaculty of Science, University of South Bohemia in České BudějoviceČeské Budějovice, CzechiaInstitute of Parasitology, Biology Center, Czech Academy of SciencesČeské Budějovice, CzechiaFaculty of Science, University of South Bohemia in České BudějoviceČeské Budějovice, CzechiaInstitute of Parasitology, Biology Center, Czech Academy of SciencesČeské Budějovice, CzechiaInstitute of Parasitology, Biology Center, Czech Academy of SciencesČeské Budějovice, CzechiaThe publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kunitz inhibitors, serpins, and cystatins. Kunitz inhibitors are anti-hemostatic agents and tens of proteins with one or more Kunitz domains are known to block host coagulation and/or platelet aggregation. Serpins and cystatins are also anti-hemostatic effectors, but intriguingly, from the translational perspective, also act as pluripotent modulators of the host immune system. Here we focus especially on this latter aspect of protease inhibition by ticks and describe the current knowledge and data on secreted salivary serpins and cystatins and their role in tick-host-pathogen interaction triad. We also discuss the potential therapeutic use of tick protease inhibitors.http://journal.frontiersin.org/article/10.3389/fcimb.2017.00216/fulltick-host interactionimmunomodulationprotease inhibitorsserpinscystatins |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jindřich Chmelař Jan Kotál Jan Kotál Helena Langhansová Helena Langhansová Michail Kotsyfakis |
spellingShingle |
Jindřich Chmelař Jan Kotál Jan Kotál Helena Langhansová Helena Langhansová Michail Kotsyfakis Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction Frontiers in Cellular and Infection Microbiology tick-host interaction immunomodulation protease inhibitors serpins cystatins |
author_facet |
Jindřich Chmelař Jan Kotál Jan Kotál Helena Langhansová Helena Langhansová Michail Kotsyfakis |
author_sort |
Jindřich Chmelař |
title |
Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction |
title_short |
Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction |
title_full |
Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction |
title_fullStr |
Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction |
title_full_unstemmed |
Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction |
title_sort |
protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2017-05-01 |
description |
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kunitz inhibitors, serpins, and cystatins. Kunitz inhibitors are anti-hemostatic agents and tens of proteins with one or more Kunitz domains are known to block host coagulation and/or platelet aggregation. Serpins and cystatins are also anti-hemostatic effectors, but intriguingly, from the translational perspective, also act as pluripotent modulators of the host immune system. Here we focus especially on this latter aspect of protease inhibition by ticks and describe the current knowledge and data on secreted salivary serpins and cystatins and their role in tick-host-pathogen interaction triad. We also discuss the potential therapeutic use of tick protease inhibitors. |
topic |
tick-host interaction immunomodulation protease inhibitors serpins cystatins |
url |
http://journal.frontiersin.org/article/10.3389/fcimb.2017.00216/full |
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