Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these prototypic adamantane inhibitors of the influenza A virus (IAV) M2 proton...

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Bibliographic Details
Main Authors: Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
hepatitis c virus
p7
viroporin
antiviral drugs
virion egress
virus entry
Online Access:https://elifesciences.org/articles/52555

Internet

https://elifesciences.org/articles/52555

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