Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound
Purpose Dynamic contrast-enhanced ultrasound (DCE-US) can be used for calculating organ perfusion. By combining bolus injection with burst replenishment, the actual mean transit time (MTT) can be estimated. Blood volume (BV) can be obtained by scaling the data to a vessel on the imaging plane. The s...
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doaj-340929666c5a4f7585ba9da7b9cd34fc2021-04-02T11:24:11ZengGeorg Thieme Verlag KGUltrasound International Open2509-596X2199-71522017-06-010303E99E10610.1055/s-0043-110475Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced UltrasoundMarcus Stangeland0Trond Engjom1Martin Mezl2Radovan Jirik3Odd Helge Gilja4Georg Dimcevski5Kim Nylund6Department of Clinical Medicine, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayDept. of Biomedical Engineering, Brno Univ. of Technology, Brno, Czech RepublicAcademy of Sciences of the Czech Republic, Institute of Scientific Instruments, Brno, Czech RepublicDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayNational Center of Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, NorwayPurpose Dynamic contrast-enhanced ultrasound (DCE-US) can be used for calculating organ perfusion. By combining bolus injection with burst replenishment, the actual mean transit time (MTT) can be estimated. Blood volume (BV) can be obtained by scaling the data to a vessel on the imaging plane. The study aim was to test interobserver agreement for repeated recordings using the same ultrasound scanner and agreement between results on two different scanner systems. Materials and Methods Ten patients under evaluation for exocrine pancreatic failure were included. Each patient was scanned two times on a GE Logiq E9 scanner, by two different observers, and once on a Philips IU22 scanner, after a bolus of 1.5 ml Sonovue. A 60-second recording of contrast enhancement was performed before the burst and the scan continued for another 30 s for reperfusion. We performed data analysis using MATLAB-based DCE-US software. An artery in the same depth as the region of interest (ROI) was used for scaling. The measurements were compared using the intraclass correlation coefficient (ICC) and Bland Altman plots. Results The interobserver agreement on the Logiq E9 for MTT (ICC=0.83, confidence interval (CI) 0.46–0.96) was excellent. There was poor agreement for MTT between the Logiq E9 and the IU22 (ICC=−0.084, CI −0.68–0.58). The interobserver agreement for blood volume measurements was excellent on the Logiq E9 (ICC=0.9286, CI 0.7250–0.98) and between scanners (ICC=0.86, CI=0.50–0.97). Conclusion Interobserver agreement was excellent using the same scanner for both parameters and between scanners for BV, but the comparison between two scanners did not yield acceptable agreement for MTT. This was probably due to incomplete bursting of bubbles in some of the recordings on the IU22.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-110475interobserverdynamic contrast-enhanced ultrasoundperfusionpancreas |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcus Stangeland Trond Engjom Martin Mezl Radovan Jirik Odd Helge Gilja Georg Dimcevski Kim Nylund |
spellingShingle |
Marcus Stangeland Trond Engjom Martin Mezl Radovan Jirik Odd Helge Gilja Georg Dimcevski Kim Nylund Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound Ultrasound International Open interobserver dynamic contrast-enhanced ultrasound perfusion pancreas |
author_facet |
Marcus Stangeland Trond Engjom Martin Mezl Radovan Jirik Odd Helge Gilja Georg Dimcevski Kim Nylund |
author_sort |
Marcus Stangeland |
title |
Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound |
title_short |
Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound |
title_full |
Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound |
title_fullStr |
Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound |
title_full_unstemmed |
Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound |
title_sort |
interobserver variation of the bolus-and-burst method for pancreatic perfusion with dynamic – contrast-enhanced ultrasound |
publisher |
Georg Thieme Verlag KG |
series |
Ultrasound International Open |
issn |
2509-596X 2199-7152 |
publishDate |
2017-06-01 |
description |
Purpose Dynamic contrast-enhanced ultrasound (DCE-US) can be used for calculating organ perfusion. By combining bolus injection with burst replenishment, the actual mean transit time (MTT) can be estimated. Blood volume (BV) can be obtained by scaling the data to a vessel on the imaging plane. The study aim was to test interobserver agreement for repeated recordings using the same ultrasound scanner and agreement between results on two different scanner systems.
Materials and Methods Ten patients under evaluation for exocrine pancreatic failure were included. Each patient was scanned two times on a GE Logiq E9 scanner, by two different observers, and once on a Philips IU22 scanner, after a bolus of 1.5 ml Sonovue. A 60-second recording of contrast enhancement was performed before the burst and the scan continued for another 30 s for reperfusion. We performed data analysis using MATLAB-based DCE-US software. An artery in the same depth as the region of interest (ROI) was used for scaling. The measurements were compared using the intraclass correlation coefficient (ICC) and Bland Altman plots.
Results The interobserver agreement on the Logiq E9 for MTT (ICC=0.83, confidence interval (CI) 0.46–0.96) was excellent. There was poor agreement for MTT between the Logiq E9 and the IU22 (ICC=−0.084, CI −0.68–0.58). The interobserver agreement for blood volume measurements was excellent on the Logiq E9 (ICC=0.9286, CI 0.7250–0.98) and between scanners (ICC=0.86, CI=0.50–0.97).
Conclusion Interobserver agreement was excellent using the same scanner for both parameters and between scanners for BV, but the comparison between two scanners did not yield acceptable agreement for MTT. This was probably due to incomplete bursting of bubbles in some of the recordings on the IU22. |
topic |
interobserver dynamic contrast-enhanced ultrasound perfusion pancreas |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-110475 |
work_keys_str_mv |
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