Single oral dose pharmacokinetics of decursin and decursinol angelate in healthy adult men and women.

Single oral dose pharmacokinetics of decursin and decursinol angelate in healthy adult men and women.

<h4>Unlabelled</h4>The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others h...

Full description

Bibliographic Details
Main Authors:	Jinhui Zhang, Li Li, Thomas W Hale, Wayne Chee, Chengguo Xing, Cheng Jiang, Junxuan Lü
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0114992

Similar Items

Simultaneous Determination of Decursin, Decursinol Angelate, Nodakenin, and Decursinol of Angelica gigas Nakai in Human Plasma by UHPLC-MS/MS: Application to Pharmacokinetic Study
by: Sook-Jin Kim, et al.
Published: (2018-04-01)

Rapid and Efficient Separation of Decursin and Decursinol Angelate from <i>Angelica gigas</i> Nakai using Ionic Liquid, (BMIm)BF<sub>4</sub>, Combined with Crystallization
by: Alice Nguvoko Kiyonga, et al.
Published: (2019-06-01)

Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet
by: Ui-Jin Bae, et al.
Published: (2017-04-01)

Antifungal Activity of Decursinol Angelate Isolated from Angelica gigas Roots Against Puccinia recondita
by: Mi-Young Yoon, et al.
Published: (2011-04-01)

Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis
by: Sukkum Ngullie Chang, et al.
Published: (2021-04-01)

Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NFκB and MAPK Signaling Pathways
by: Salman Ul Islam, et al.
Published: (2018-07-01)

Decursinol from Angelica gigas Nakai enhances endometrial receptivity during implantation
by: Seong-Eun Kim, et al.
Published: (2020-02-01)

Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses
by: Wu GL, et al.
Published: (2015-10-01)

Effects of rifampicin and ketoconazole on the pharmacokinetics of a single oral dose of diethylcarbamazine in healthy volunteers
by: W Ridtitid, et al.
Published: (2006-12-01)

Pharmacokinetics of Single-Dose Oral Pregabalin Administration in Normal Cats
by: Michaela A. Esteban, et al.
Published: (2018-07-01)

Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs
by: Hyuck-Joo Yang, et al.
Published: (2018-09-01)

Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects
by: Kirsch Lee E, et al.
Published: (2009-12-01)

Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model
by: Dang Bao Son, et al.
Published: (2021-03-01)

Pharmacokinetics and Bioavailability Study of a Prednisolone Tablet as a Single Oral Dose in Bangladeshi Healthy Volunteers
by: Tafsir Bashar MPharm, et al.
Published: (2018-07-01)

Pharmacokinetic Study of Frovatriptan Succinate Tablet After Single and Multiple Oral Doses in Chinese Healthy Subjects
by: Zheng H, et al.
Published: (2021-07-01)

Pharmacokinetics of Oral Prulifloxacin Capsules in Healthy Volunteers
by: Jing Zou, et al.
Published: (2011-03-01)

Pharmacokinetics and Dose Proportionality of Betahistine in Healthy Individuals
by: Duaa J. Al-Tamimi, et al.
Published: (2020-03-01)

Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke.
by: Bing Chun Yan, et al.
Published: (2013-01-01)

Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects
by: Sheng L, et al.
Published: (2021-03-01)

Sultiame pharmacokinetic profile in plasma and erythrocytes after single oral doses: A pilot study in healthy volunteers
by: Kim Dao, et al.
Published: (2020-02-01)

Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects
by: Xiaoshu Dai, et al.
Published: (2021-02-01)

Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population
by: Xueqing Li, et al.
Published: (2017-11-01)

Pharmacokinetics and tolerability of apremilast in healthy Korean adult men
by: Ki Young Huh, et al.
Published: (2021-07-01)

Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers
by: Himanshu Naik, et al.
Published: (2021-07-01)

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers
by: Kim YH, et al.
Published: (2015-03-01)

Effect of <i>Angelica gigas</i> Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells
by: Bitna Kweon, et al.
Published: (2020-04-01)

A Single- and Multiple-Dose Study to Evaluate the Pharmacokinetics of Fixed-Dose Grazoprevir/Elbasvir in Healthy Chinese Participants
by: Li H, et al.
Published: (2020-02-01)

Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers
by: Zeyun Li, et al.
Published: (2021-07-01)

Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats
by: Kelly A. Deabold, et al.
Published: (2019-10-01)

Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men.
by: Fabian Y S Kong, et al.
Published: (2017-01-01)

Pharmacokinetics and relative bioavailability of fixed-dose combination of clopidogrel and aspirin versus coadministration of individual formulations in healthy Korean men
by: Choi HK, et al.
Published: (2016-10-01)

Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects
by: Cui Y, et al.
Published: (2013-12-01)

Single dose pharmacokinetic equivalence study of two gabapentin preparations in healthy subjects
by: Tjandrawinata RR, et al.
Published: (2014-09-01)

Evaluation of the single-dose pharmacokinetics and pharmacodynamics of apixaban in healthy Japanese and Caucasian subjects
by: Frost C, et al.
Published: (2018-10-01)

Single dose oral ranolazine pharmacokinetics in patients receiving maintenance hemodialysis
by: Bridget A. Scoville, et al.
Published: (2019-01-01)

Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects
by: Michiel J. vanEsdonk, et al.
Published: (2018-09-01)

Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats
by: Liana M. Yates, et al.
Published: (2020-02-01)

Pharmacokinetics and pharmacodynamics of oral meloxicam tablets in healthy horses
by: Vander Werf, Karie
Published: (2013)

Single- and Multiple-Dose Trials to Determine the Pharmacokinetics, Safety, Tolerability, and Sex Effect of Oral Ginsenoside Compound K in Healthy Chinese Volunteers
by: Lulu Chen, et al.
Published: (2018-01-01)

The effect of multiple doses of ubrogepant on the pharmacokinetics of an oral contraceptive in healthy women: Results of an open-label, single-center, two-period, fixed-sequence study
by: Chi-Chung Li, et al.
Published: (2020-02-01)

Cannot write session to /tmp/vufind_sessions/sess_dn2s98ullgqegno3m2put35edq