Development of a fluorogenic ADAMTS-7 substrate

Development of a fluorogenic ADAMTS-7 substrate

The extracellular protease ADAMTS-7 has been identified as a potential therapeutic target in atherosclerosis and associated diseases such as coronary artery disease (CAD). However, ADAMTS-7 inhibitors have not been reported so far. Screening of inhibitors has been hindered by the lack of a suitable...

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Bibliographic Details
Main Authors: Salvatore Santamaria, Frederic Buemi, Elisa Nuti, Doretta Cuffaro, Elena De Vita, Tiziano Tuccinardi, Armando Rossello, Steven Howell, Shahid Mehmood, Ambrosius P. Snijders, Rens de Groot
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
adamts-7
adamts7
activity assay
inhibitor
coronary artery disease
Online Access:http://dx.doi.org/10.1080/14756366.2021.1983808

Internet

http://dx.doi.org/10.1080/14756366.2021.1983808

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