CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

We report that CD47 was upregulated in different EMT-activated human breast cancer cells versus epithelial MCF7 cells. Overexpression of SNAI1 or ZEB1 in epithelial MCF7 cells activated EMT and upregulated CD47 while siRNA-mediated targeting of SNAI1 or ZEB1 in mesenchymal MDA-MB-231 cells reversed...

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Bibliographic Details
Main Authors: Muhammad Zaeem Noman, Kris Van Moer, Vanessa Marani, Robert M. Gemmill, Léon-Charles Tranchevent, Francisco Azuaje, Arnaud Muller, Salem Chouaib, Jean Paul Thiery, Guy Berchem, Bassam Janji
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
breast cancer
cd47
dendritic cells
epithelial to mesenchymal transition
immune checkpoint
macrophage
phagocytosis and immunotherapy
zeb1
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1345415

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