A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.

Bibliographic Details
Main Authors:	Jlenia Guarnerio, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S. Frenette, Keisuke Ito, Pier Paolo Pandolfi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02427-x

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spelling	doaj-342cc2d1a19c42458ab298d79230142d2021-05-11T09:21:42ZengNature Publishing GroupNature Communications2041-17232018-01-019111110.1038/s41467-017-02427-xA non-cell-autonomous role for Pml in the maintenance of leukemia from the nicheJlenia Guarnerio0Lourdes Maria Mendez1Noboru Asada2Archita Venugopal Menon3Jacqueline Fung4Kelsey Berry5Paul S. Frenette6Keisuke Ito7Pier Paolo Pandolfi8Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price CenterCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price CenterRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price CenterCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolPersistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.https://doi.org/10.1038/s41467-017-02427-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi
spellingShingle	Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche Nature Communications
author_facet	Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi
author_sort	Jlenia Guarnerio
title	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_short	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_full	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_fullStr	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_full_unstemmed	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_sort	non-cell-autonomous role for pml in the maintenance of leukemia from the niche
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.
url	https://doi.org/10.1038/s41467-017-02427-x
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A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

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