A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.
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2018-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02427-x |
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doaj-342cc2d1a19c42458ab298d79230142d2021-05-11T09:21:42ZengNature Publishing GroupNature Communications2041-17232018-01-019111110.1038/s41467-017-02427-xA non-cell-autonomous role for Pml in the maintenance of leukemia from the nicheJlenia Guarnerio0Lourdes Maria Mendez1Noboru Asada2Archita Venugopal Menon3Jacqueline Fung4Kelsey Berry5Paul S. Frenette6Keisuke Ito7Pier Paolo Pandolfi8Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price CenterCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price CenterRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price CenterCancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolPersistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.https://doi.org/10.1038/s41467-017-02427-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi |
spellingShingle |
Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche Nature Communications |
author_facet |
Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi |
author_sort |
Jlenia Guarnerio |
title |
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche |
title_short |
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche |
title_full |
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche |
title_fullStr |
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche |
title_full_unstemmed |
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche |
title_sort |
non-cell-autonomous role for pml in the maintenance of leukemia from the niche |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-01-01 |
description |
Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy. |
url |
https://doi.org/10.1038/s41467-017-02427-x |
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