A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.
Main Authors: | Jlenia Guarnerio, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S. Frenette, Keisuke Ito, Pier Paolo Pandolfi |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-01-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02427-x |
Similar Items
-
PML degradation: multiple ways to eliminate PML.
by: Andrea eRabellino, et al.
Published: (2013-03-01) -
Newly identified roles of PML in stem cell biology
by: Keisuke eIto, et al.
Published: (2013-03-01) -
A dialogue on the first 20 years of PML research and the next 20 ahead
by: Pier Paolo ePandolfi, et al.
Published: (2014-02-01) -
Disruption of Transcription by the Oncogene PML-RARα in Acute Promyelocytic Leukemia and Regulation of the Tumor Suppressor PML in Breast Cancer
by: Reineke, Erin Lynn
Published: (2008) -
Is PML a tumor suppressor?
by: Massimiliano eMazza, et al.
Published: (2013-07-01)