Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells

Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells

<p>Abstract</p> <p>Background</p> <p>Pirfenidone is a novel anti-fibrotic and anti-inflammatory agent that inhibits the progression of fibrosis in animal models and in patients with idiopathic pulmonary fibrosis (IPF). We previously showed that pirfenidone inhibits the...

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Bibliographic Details
Main Authors: Hisatomi Keiko, Mukae Hiroshi, Sakamoto Noriho, Ishimatsu Yuji, Kakugawa Tomoyuki, Hara Shintaro, Fujita Hanako, Nakamichi Seiko, Oku Hisashi, Urata Yoshishige, Kubota Hiroshi, Nagata Kazuhiro, Kohno Shigeru
Format: Article
Language:English
Published: BMC 2012-06-01
Series:BMC Pulmonary Medicine
Subjects:
Pneumocyte
Interstitial pneumonia
Epithelial cell
Epithelial mesenchymal transition
Pulmonary fibrosis
Online Access:http://www.biomedcentral.com/1471-2466/12/24

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