| Summary: | P. sarmentosum possesses a variety of biological activities and has long been used as a food ingredient and traditional
medicine to treat many diseases. In this study, its mutagenic and genotoxic activities on S. typhimurium TA98 and TA100 and
fibroblast (V79) cells were examined. Mediated by S9 activation, the water extract of P. sarmentosum at a high dose caused the
number of revertant colonies to increase in the tester strains TA98 (20 mg/plate) and TA100 (40 mg/plate), but there was no
mutagenic effect in the presence of S9 in mixed condition. The extract (1 - 7.5 mg/ml) showed no significant genotoxic effect
based on the frequency of micronucleus formation both with and without S9 in mixed conditions. In conclusion, the water extract
of P. sarmentosum has neither direct nor indirect genotoxic effects and has no mutagenic effects indirectly. Therefore, the results
indicate that P. sarmentosum is safe for use as a food supplement.
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