Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan

The mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to colistin by transferring phosphoethanolamine to lipid A. A 33-kb IncX4 plasmid harboring mcr-1 was detected in a Klebsiella pneumoniae isolate and two Escherichia coli isolates, and a 66-kb IncI2 plasmid was detected...

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Main Authors:	Tatsuya Tada, Kohei Uechi, Isamu Nakasone, Masashi Nakamatsu, Kazuhito Satou, Takashi Hirano, Teruo Kirikae, Jiro Fujita
Format:	Article
Language:	English
Published:	Elsevier 2018-10-01
Series:	International Journal of Infectious Diseases
Online Access:	http://www.sciencedirect.com/science/article/pii/S1201971218344989

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spelling	doaj-3448743cc81843889addb2ee60d896d42020-11-24T22:14:51ZengElsevierInternational Journal of Infectious Diseases1201-97122018-10-017598100Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in JapanTatsuya Tada0Kohei Uechi1Isamu Nakasone2Masashi Nakamatsu3Kazuhito Satou4Takashi Hirano5Teruo Kirikae6Jiro Fujita7Department of Microbiology, Juntendo University School of Medicine, Tokyo, JapanDivision of Clinical Laboratory and Blood Transfusion, University Hospital of the Ryukyus, Okinawa, Japan; Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanControl and Prevention of Infectious Disease, University Hospital of the Ryukyus, Okinawa, JapanDepartment of Infectious Diseases, Faculty of the Ryukyus, Okinawa, JapanOkinawa Institute of Advanced Science, Okinawa, Japan; Department of Genome Medicine, Research Institute, National Center for Children Health and Development, Tokyo, JapanOkinawa Institute of Advanced Science, Okinawa, JapanDepartment of Microbiology, Juntendo University School of Medicine, Tokyo, Japan; Corresponding author at: Department of Microbiology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanThe mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to colistin by transferring phosphoethanolamine to lipid A. A 33-kb IncX4 plasmid harboring mcr-1 was detected in a Klebsiella pneumoniae isolate and two Escherichia coli isolates, and a 66-kb IncI2 plasmid was detected in three E. coli isolates in hospitals in Okinawa, Japan. Keywords: Colistin resistance, MCR-1 producing Klebsiella pneumoniae, IncX4 plasmid harboring mcr-1http://www.sciencedirect.com/science/article/pii/S1201971218344989
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tatsuya Tada Kohei Uechi Isamu Nakasone Masashi Nakamatsu Kazuhito Satou Takashi Hirano Teruo Kirikae Jiro Fujita
spellingShingle	Tatsuya Tada Kohei Uechi Isamu Nakasone Masashi Nakamatsu Kazuhito Satou Takashi Hirano Teruo Kirikae Jiro Fujita Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan International Journal of Infectious Diseases
author_facet	Tatsuya Tada Kohei Uechi Isamu Nakasone Masashi Nakamatsu Kazuhito Satou Takashi Hirano Teruo Kirikae Jiro Fujita
author_sort	Tatsuya Tada
title	Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan
title_short	Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan
title_full	Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan
title_fullStr	Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan
title_full_unstemmed	Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan
title_sort	emergence of incx4 plasmids encoding mcr-1 in a clinical isolate of klebsiella pneumoniae in japan
publisher	Elsevier
series	International Journal of Infectious Diseases
issn	1201-9712
publishDate	2018-10-01
description	The mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to colistin by transferring phosphoethanolamine to lipid A. A 33-kb IncX4 plasmid harboring mcr-1 was detected in a Klebsiella pneumoniae isolate and two Escherichia coli isolates, and a 66-kb IncI2 plasmid was detected in three E. coli isolates in hospitals in Okinawa, Japan. Keywords: Colistin resistance, MCR-1 producing Klebsiella pneumoniae, IncX4 plasmid harboring mcr-1
url	http://www.sciencedirect.com/science/article/pii/S1201971218344989
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Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan

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