Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy

Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy

Evans syndrome (ES) is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Intravascular hemolysis, with hemoglobinemia, is known to produce acute...

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Main Authors: Iván González, Rehan Rais, Joseph P. Gaut, Louis P. Dehner
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Pediatrics
Online Access:http://dx.doi.org/10.1155/2017/5184587
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spelling doaj-3455439bccd348209726dc547716cbed2020-11-24T22:24:04ZengHindawi LimitedCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/51845875184587Evans Syndrome Complicated by Intratubular Hemoglobin Cast NephropathyIván González0Rehan Rais1Joseph P. Gaut2Louis P. Dehner3The Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAThe Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAThe Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAThe Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAEvans syndrome (ES) is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Intravascular hemolysis, with hemoglobinemia, is known to produce acute kidney injury; however, the development of intratubular hemoglobin casts (hemoglobin cast nephropathy) in the setting of acute hemolysis is uncommon. Likewise, the association of ES and acute renal failure is equally uncommon. We present a case of a 7-year-old girl with ES who developed acute kidney injury in the setting of intravascular hemolysis and had widespread intratubular hemoglobin casts.http://dx.doi.org/10.1155/2017/5184587
collection DOAJ
language English
format Article
sources DOAJ
author Iván González
Rehan Rais
Joseph P. Gaut
Louis P. Dehner
spellingShingle Iván González
Rehan Rais
Joseph P. Gaut
Louis P. Dehner
Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy
Case Reports in Pediatrics
author_facet Iván González
Rehan Rais
Joseph P. Gaut
Louis P. Dehner
author_sort Iván González
title Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy
title_short Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy
title_full Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy
title_fullStr Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy
title_full_unstemmed Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy
title_sort evans syndrome complicated by intratubular hemoglobin cast nephropathy
publisher Hindawi Limited
series Case Reports in Pediatrics
issn 2090-6803
2090-6811
publishDate 2017-01-01
description Evans syndrome (ES) is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Intravascular hemolysis, with hemoglobinemia, is known to produce acute kidney injury; however, the development of intratubular hemoglobin casts (hemoglobin cast nephropathy) in the setting of acute hemolysis is uncommon. Likewise, the association of ES and acute renal failure is equally uncommon. We present a case of a 7-year-old girl with ES who developed acute kidney injury in the setting of intravascular hemolysis and had widespread intratubular hemoglobin casts.
url http://dx.doi.org/10.1155/2017/5184587
work_keys_str_mv AT ivangonzalez evanssyndromecomplicatedbyintratubularhemoglobincastnephropathy
AT rehanrais evanssyndromecomplicatedbyintratubularhemoglobincastnephropathy
AT josephpgaut evanssyndromecomplicatedbyintratubularhemoglobincastnephropathy
AT louispdehner evanssyndromecomplicatedbyintratubularhemoglobincastnephropathy
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