Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy
Evans syndrome (ES) is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Intravascular hemolysis, with hemoglobinemia, is known to produce acute...
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Hindawi Limited
2017-01-01
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Series: | Case Reports in Pediatrics |
Online Access: | http://dx.doi.org/10.1155/2017/5184587 |
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doaj-3455439bccd348209726dc547716cbed2020-11-24T22:24:04ZengHindawi LimitedCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/51845875184587Evans Syndrome Complicated by Intratubular Hemoglobin Cast NephropathyIván González0Rehan Rais1Joseph P. Gaut2Louis P. Dehner3The Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAThe Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAThe Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAThe Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children’s Hospital, Washington University Medical Center, St. Louis, MO, USAEvans syndrome (ES) is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Intravascular hemolysis, with hemoglobinemia, is known to produce acute kidney injury; however, the development of intratubular hemoglobin casts (hemoglobin cast nephropathy) in the setting of acute hemolysis is uncommon. Likewise, the association of ES and acute renal failure is equally uncommon. We present a case of a 7-year-old girl with ES who developed acute kidney injury in the setting of intravascular hemolysis and had widespread intratubular hemoglobin casts.http://dx.doi.org/10.1155/2017/5184587 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iván González Rehan Rais Joseph P. Gaut Louis P. Dehner |
spellingShingle |
Iván González Rehan Rais Joseph P. Gaut Louis P. Dehner Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy Case Reports in Pediatrics |
author_facet |
Iván González Rehan Rais Joseph P. Gaut Louis P. Dehner |
author_sort |
Iván González |
title |
Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy |
title_short |
Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy |
title_full |
Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy |
title_fullStr |
Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy |
title_full_unstemmed |
Evans Syndrome Complicated by Intratubular Hemoglobin Cast Nephropathy |
title_sort |
evans syndrome complicated by intratubular hemoglobin cast nephropathy |
publisher |
Hindawi Limited |
series |
Case Reports in Pediatrics |
issn |
2090-6803 2090-6811 |
publishDate |
2017-01-01 |
description |
Evans syndrome (ES) is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Intravascular hemolysis, with hemoglobinemia, is known to produce acute kidney injury; however, the development of intratubular hemoglobin casts (hemoglobin cast nephropathy) in the setting of acute hemolysis is uncommon. Likewise, the association of ES and acute renal failure is equally uncommon. We present a case of a 7-year-old girl with ES who developed acute kidney injury in the setting of intravascular hemolysis and had widespread intratubular hemoglobin casts. |
url |
http://dx.doi.org/10.1155/2017/5184587 |
work_keys_str_mv |
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1725762505913925632 |