Treatment of Leukocytospermia in Male Infertility: A Systematic Review
Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and the urogenital tract. Although great...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2016-12-01
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| Series: | The World Journal of Men's Health |
| Subjects: | |
| Online Access: | https://www.wjmh.org/Synapse/Data/PDFData/2074WJMH/wjmh-34-165.pdf |
| Summary: | Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in
up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and
the urogenital tract. Although great deal of effort has been expended to elucidate definite management strategies in infertile men
with leukocytospermia, the gold standard of treatment remains unclear. Until recently, broad spectrum antibiotics and
antioxidants have been used in the treatment of leukocytospermia for male infertility to eliminate infection and reduce reactive
oxygen free radicals produced inside cellular mitochondria as a result of inflammation. The present review reveals that antibiotics
might improve sperm parameters, the rate of resolution of leukocytospermia, the bacteriologic cure rate, and even the pregnancy
rate, although some reports conflict. Antioxidants might also have clinical benefits for sperm function as shown by in vitro studies.
However, the data are insufficient to conclude whether antibiotics and antioxidants for the treatment of infertile men with
leukocytospermia are effective or not. Better designed investigations into leukocytospermia are needed. |
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| ISSN: | 2287-4208 2287-4690 |